EVALUATION OF THE EFFECTS OF RANITIDINE AND SUCRALFATE IN PREVENTION OF GASTRIC LESIONS INDUCED BY ASPIRIN IN DOG

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KAMRANI A.R.; ALE DAVOUD S.J.; JAMSHIDI SHAHRAM; ROSTAMI A.; MARJANMEHR S.H.; MOHRI M.

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Journal: Journal of Veterinary Research Year:2002 | Volume:57 | Issue:3 Page(s): 41-47

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Title

EVALUATION OF THE EFFECTS OF RANITIDINE AND SUCRALFATE IN PREVENTION OF GASTRIC LESIONS INDUCED BY ASPIRIN IN DOG

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Keywords

SUCRALFATEQ4

RANITIDINEQ4

DOGQ2

GASTRIC LESIONSQ4

Abstract

Objective: Comparison of the protective effects of RANITIDINE with SUCRALFATE against aspirin induced gastric mucosal lesions in DOG.Design: Experimental study.Animals: eighteen healthy mongrel DOGs.Procedure: Eighteen DOGs were divided into four groups: group 1)aspirin 25 mg/kg every 12 hours. Group 2)aspirin with the above dose and RANITIDINE 150 mg/dog every 12 hours. Group3) aspirin with the above dose and SUCRALFATE 1000 mg/dog every 12 hours. Group 4) no medication. Weekly endoscopic examination was performed on all of the DOGs and observed GASTRIC LESIONS were graded. At the end of 8th week, the animals were both sacrifificed and their stomachs and duodenums were evaluated macroscopically and microscopically. Stalistial analysis: Kruskall wallis, manrwithney and sign tests. Results: Group 2 had lesser mean gastric lesion scores compared with group I in the first and third weeks. Group 2 had milder lesions with group 3 meaningfully only in the first week of study.Conclusion: RANITIDINE is effective as a protective measure against GASTRIC LESIONS induced by short telll1 use of aspirin. But SUCRALFATE is not effective neither in short term, nor in long term following use of aspirin.

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APA: Copy

KAMRANI, A.R., ALE DAVOUD, S.J., JAMSHIDI, SHAHRAM, ROSTAMI, A., MARJANMEHR, S.H., & MOHRI, M.. (2002). EVALUATION OF THE EFFECTS OF RANITIDINE AND SUCRALFATE IN PREVENTION OF GASTRIC LESIONS INDUCED BY ASPIRIN IN DOG. JOURNAL OF VETERINARY RESEARCH, 57(3), 41-47. SID. https://sid.ir/paper/34949/en

Vancouver: Copy

KAMRANI A.R., ALE DAVOUD S.J., JAMSHIDI SHAHRAM, ROSTAMI A., MARJANMEHR S.H., MOHRI M.. EVALUATION OF THE EFFECTS OF RANITIDINE AND SUCRALFATE IN PREVENTION OF GASTRIC LESIONS INDUCED BY ASPIRIN IN DOG. JOURNAL OF VETERINARY RESEARCH[Internet]. 2002;57(3):41-47. Available from: https://sid.ir/paper/34949/en

IEEE: Copy

A.R. KAMRANI, S.J. ALE DAVOUD, SHAHRAM JAMSHIDI, A. ROSTAMI, S.H. MARJANMEHR, and M. MOHRI, “EVALUATION OF THE EFFECTS OF RANITIDINE AND SUCRALFATE IN PREVENTION OF GASTRIC LESIONS INDUCED BY ASPIRIN IN DOG,” JOURNAL OF VETERINARY RESEARCH, vol. 57, no. 3, pp. 41–47, 2002, [Online]. Available: https://sid.ir/paper/34949/en

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