EXPERIMENTAL STUDY OF APOPTOSIS INDUCED BY INFECTIOUS BURSAL DISEASE VNUS, USING THNEL ASSAY

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DOUSTAR Y.; NAGSHINEH R.; TOROUGHI R.; HASHEMI M.; RAHBAR R.

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Journal: Journal of Veterinary Research Year:2005 | Volume:60 | Issue:4 Page(s): 313-320

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Title

EXPERIMENTAL STUDY OF APOPTOSIS INDUCED BY INFECTIOUS BURSAL DISEASE VNUS, USING THNEL ASSAY

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Keywords

APOPTOSISQ3

GUMBORO DISEASEQ3

INFECTIOUS BURSAL DISEASEQ4

Abstract

Objective: The purpose of the present in vivo study was to evaluate correlation of the virulence of the INFECTIOUS BURSAL DISEASE virus with the rate of apoptotic changes of the immature B lymphocytes in Bursa Fabricius (BF) and lymphoid cells of spleen.Design: Experimental study.Animals: 21-day-old SPF chicks of leghorn breed.Procedures: 90 chicks were divided into three groups (IESTIBDV, TEST -VAC and Control) of 30 chicks each.inoculation of the TEST-IBDV, TEST -VAC and Control groups were done with IR-499 serotype of high-virulence INFECTIOUS BURSAL DISEASE Virus (VVIBDV), D78 intermediate vaccine and normal saline, respectively. Furthermore, 20 chicks were categorited into two groups (Test and Control) of 10chicks each, Test and Control groups were inoculated with VVIBDV and normal saline, respectively. 3 days after inoculation, samples of BF and splenic tissues were sent to Pathology Lab for LM, H&E satinig and TUNEL studies. Statistical analysis: Kruskal-Wallis, ANOVA and Mann- Whitney test.Results: LM and H&E staining showed many significant differences among groups. Furthermore, we showed VP2&VP5, INF-gamma and TNF-alpha were the major inductive factors for development of APOPTOSIS in the immature B lymphocytes of BF and spleen.Discussion: The present in vivo research showed that there is always a significant correlation between the virulence of the virus and the rate of apoptotic changes in the BF tissue. Moreover, APOPTOSIS can be considered as a definite factor in the pathogenesis of INFECTIOUS BURSAL DISEASE (IBD).

Cites

بررسی اثرات آپوپتوزیس القا شده پروتئین ژن VP2 کلون شده از ژنوم ویروس بورس عفونی بر سلولهای سرطانی لنفوسیتی B انسان در in vitro

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APA: Copy

DOUSTAR, Y., NAGSHINEH, R., TOROUGHI, R., HASHEMI, M., & RAHBAR, R.. (2005). EXPERIMENTAL STUDY OF APOPTOSIS INDUCED BY INFECTIOUS BURSAL DISEASE VNUS, USING THNEL ASSAY. JOURNAL OF VETERINARY RESEARCH, 60(4), 313-320. SID. https://sid.ir/paper/35030/en

Vancouver: Copy

DOUSTAR Y., NAGSHINEH R., TOROUGHI R., HASHEMI M., RAHBAR R.. EXPERIMENTAL STUDY OF APOPTOSIS INDUCED BY INFECTIOUS BURSAL DISEASE VNUS, USING THNEL ASSAY. JOURNAL OF VETERINARY RESEARCH[Internet]. 2005;60(4):313-320. Available from: https://sid.ir/paper/35030/en

IEEE: Copy

Y. DOUSTAR, R. NAGSHINEH, R. TOROUGHI, M. HASHEMI, and R. RAHBAR, “EXPERIMENTAL STUDY OF APOPTOSIS INDUCED BY INFECTIOUS BURSAL DISEASE VNUS, USING THNEL ASSAY,” JOURNAL OF VETERINARY RESEARCH, vol. 60, no. 4, pp. 313–320, 2005, [Online]. Available: https://sid.ir/paper/35030/en

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