ANTIAPOPTOTIC EFFECT OF DEPRENYL IN SENSORY NEURONS OF RAT DORSAL ROOT GANGLION AFTER SCIATIC NERVE TRANSACTION

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HOBENAGHI R.; TIRAIHI T.

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Journal: Journal of Veterinary Research Year:2005 | Volume:60 | Issue:1 Page(s): 65-69

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Title

ANTIAPOPTOTIC EFFECT OF DEPRENYL IN SENSORY NEURONS OF RAT DORSAL ROOT GANGLION AFTER SCIATIC NERVE TRANSACTION

Author(s)

HOBENAGHI R. | TIRAIHI T. | Issue Writer Certificate

Keywords

APOPTOSISQ2

AXOTOMYQ4

DORSAL ROOT GANGLIONQ4

DEPRENYLQ4

Abstract

Objective: Study on antiapoptotic effect of DEPRENYL in sensory neurons of DORSAL ROOT GANGLION of rat.Animals: White Sprague-Dawley rats. The regions of operation were sciatic nerve in midthigh and L dorsal root 5 ganglion.Procedure: New born rats (3rd days) were divided into five groups and their left side sciatic nerves were transected at midthigh region. Five test groups were administered by DEPRENYL in different doses of: 0.1, 1, 10, 25 and 50 mg/Kg and the antiapoptotic effect of drug were compared with control group.Statistical analysis: The values obtained from each test groups were compared with control group by t-test and oneway ANOVA.Results: The results showed that treatment of animal with DEPRENYL prevented reduction in neurons number, in dose dependent manner. The group treated with dose 25mg/Kg showed the better results. Conclusion: DEPRENYL is able to prevent the induction of APOPTOSIS in axotomized and nonaxotomized neurons.

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APA: Copy

HOBENAGHI, R., & TIRAIHI, T.. (2005). ANTIAPOPTOTIC EFFECT OF DEPRENYL IN SENSORY NEURONS OF RAT DORSAL ROOT GANGLION AFTER SCIATIC NERVE TRANSACTION. JOURNAL OF VETERINARY RESEARCH, 60(1), 65-69. SID. https://sid.ir/paper/35110/en

Vancouver: Copy

HOBENAGHI R., TIRAIHI T.. ANTIAPOPTOTIC EFFECT OF DEPRENYL IN SENSORY NEURONS OF RAT DORSAL ROOT GANGLION AFTER SCIATIC NERVE TRANSACTION. JOURNAL OF VETERINARY RESEARCH[Internet]. 2005;60(1):65-69. Available from: https://sid.ir/paper/35110/en

IEEE: Copy

R. HOBENAGHI, and T. TIRAIHI, “ANTIAPOPTOTIC EFFECT OF DEPRENYL IN SENSORY NEURONS OF RAT DORSAL ROOT GANGLION AFTER SCIATIC NERVE TRANSACTION,” JOURNAL OF VETERINARY RESEARCH, vol. 60, no. 1, pp. 65–69, 2005, [Online]. Available: https://sid.ir/paper/35110/en

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