NITRIC OXIDE MEDIATED NON-ADRENERGIC NON-CHOLINERGIC SYSTEM IN SHEEP CORONARY ARTERIES

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ARAB H.A.; HOSSEINZADEH F.

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Journal: Journal of Veterinary Research Year:2004 | Volume:59 | Issue:2 Page(s): 109-114

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Information Journal Paper

Title

NITRIC OXIDE MEDIATED NON-ADRENERGIC NON-CHOLINERGIC SYSTEM IN SHEEP CORONARY ARTERIES

Author(s)

ARAB H.A. | HOSSEINZADEH F. | Issue Writer Certificate

Keywords

SHEEP CORONARYQ4

NITRIC OXIDEQ2

NON ADRENERGIC NON CHOLINERGICQ4

Abstract

Objective: This study aimed to examine the role of NITRIC OXIDE (NO) as mediator of non-adrenergic non-cholinergic (NANC) system in coronary arteries of sheep. Design: In vitro study. Samples: Sixteen hearts of sheep aged 8-10 months. Procedure: In vitro experiments were conducted using isolated tissue preparations. The isolated tissues were obtained from the left coronary arteries of hearts collected from lambs aged 8-10 months. They were mounted in organ bath system to record the isometric forces by a physiograph. The tissues were suspended in 37°c Krebs" solution bubbled with 95% oxygen and 5% CO2. Four experimental groups were prepared and the isolated tissues were treated with 5×l0-5 M acetyl choline (Ach), an inhibitor of NO synthethase, nitro- L- arginine methyl ester (L-NAME) and L-arginine (L-arg) as precursor for NO. Statistical analysis: Student t-test. Results: The tissues treated with Ach contracted for a short time before they were relaxed permanently. The relaxation induced by Ach was dependent on the viability of endothelium. The pretreatment of tissues with L-NAME, not only decreased the relaxation induced by Ach, but also significantly (P<0.02) increased the level of tissue contraction. It was also found that (L-arg) was significantly able to decrease the primary contraction induced by Ach (P<0.01) as well as reducing the effects of L-NAME on coronary arteries of sheep and the results of this study further suggest that there are different types of muscarinic receptors in SHEEP CORONARY arteries. Conclusion: The results of this study showed that a NANC system mediated by No is present in SHEEP CORONARY arteries and also approved the findings that there are different Achreceptors in these arteries.

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APA: Copy

ARAB, H.A., & HOSSEINZADEH, F.. (2004). NITRIC OXIDE MEDIATED NON-ADRENERGIC NON-CHOLINERGIC SYSTEM IN SHEEP CORONARY ARTERIES. JOURNAL OF VETERINARY RESEARCH, 59(2), 109-114. SID. https://sid.ir/paper/35150/en

Vancouver: Copy

ARAB H.A., HOSSEINZADEH F.. NITRIC OXIDE MEDIATED NON-ADRENERGIC NON-CHOLINERGIC SYSTEM IN SHEEP CORONARY ARTERIES. JOURNAL OF VETERINARY RESEARCH[Internet]. 2004;59(2):109-114. Available from: https://sid.ir/paper/35150/en

IEEE: Copy

H.A. ARAB, and F. HOSSEINZADEH, “NITRIC OXIDE MEDIATED NON-ADRENERGIC NON-CHOLINERGIC SYSTEM IN SHEEP CORONARY ARTERIES,” JOURNAL OF VETERINARY RESEARCH, vol. 59, no. 2, pp. 109–114, 2004, [Online]. Available: https://sid.ir/paper/35150/en

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