ROLE OF CENTRAL GABAB RECEPTOR IN CONTROL OF ESTRAIDOL HORMONES SECRETION DURING PROESTRUS PHASE IN FEMALE RATS

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TAHERIANFARD M.; BAHA ALDINI A.; BAHREHBAR M.; RAJAEIAN H.

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Journal: Journal of Veterinary Research Year:2006 | Volume:61 | Issue:3 Page(s): 273-276

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Title

ROLE OF CENTRAL GABAB RECEPTOR IN CONTROL OF ESTRAIDOL HORMONES SECRETION DURING PROESTRUS PHASE IN FEMALE RATS

Author(s)

TAHERIANFARD M. | BAHA ALDINI A. | BAHREHBAR M. | RAJAEIAN H. | Issue Writer Certificate

Keywords

ESTRADIOLQ3

PROGESTERONEQ3

BACLOFENQ4

CGP35348Q4

PROESTRUSQ3

FEMALE RATQ3

Abstract

Objective: The effect of ICV injection of BACLOFEN (GABAB agonist) and CGP35348 (GABAB antagonist) on serum concentration of ESTRADIOL and PROGESTERONE in proestrous phase. Design: Experimental study.Animals: Twenty female Sperague Dawley rats weighning 200-250 g were used.Procedure: For ICV injection a director canula was inserted into the lateral ventricle by stereotaxic surgery. Each injection was performed 30 min before blood sampling. Blood samples were collected 9, 11 and 13h after initiation of proestrous.ESTRADIOL and PROGESTERONE levels were determined using RIA method.Statistical analysis: Data were analyzed by One Way ANOVA, repeated mature ANOVA and post-hoc Tucky test. The level of significance was at P<0.05.Results: Present data demonstrated that BACLOFEN at doses of 4.27 and 8.54 ng/rat significantly increased and decreased serum concentration of ESTRADIOL, respectively (p<0.05).Baclofen at the same doses significantly increased serum concentration of PROGESTERONE in 11a.m and 1p.m (P<0.05).CGP35348 in both doses had no significant effect on serum concentration of ESTRADIOL, while in 5 g/rat significantly increased the serum concentration of PROGESTERONE (P<0.05). Discussion: The results indicate that GABAB receptormay has an important role in the control of ESTRADIOL and PROGESTERONE secretion in the proestrous phase of FEMALE RATs.

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APA: Copy

TAHERIANFARD, M., BAHA ALDINI, A., BAHREHBAR, M., & RAJAEIAN, H.. (2006). ROLE OF CENTRAL GABAB RECEPTOR IN CONTROL OF ESTRAIDOL HORMONES SECRETION DURING PROESTRUS PHASE IN FEMALE RATS. JOURNAL OF VETERINARY RESEARCH, 61(3), 273-276. SID. https://sid.ir/paper/35272/en

Vancouver: Copy

TAHERIANFARD M., BAHA ALDINI A., BAHREHBAR M., RAJAEIAN H.. ROLE OF CENTRAL GABAB RECEPTOR IN CONTROL OF ESTRAIDOL HORMONES SECRETION DURING PROESTRUS PHASE IN FEMALE RATS. JOURNAL OF VETERINARY RESEARCH[Internet]. 2006;61(3):273-276. Available from: https://sid.ir/paper/35272/en

IEEE: Copy

M. TAHERIANFARD, A. BAHA ALDINI, M. BAHREHBAR, and H. RAJAEIAN, “ROLE OF CENTRAL GABAB RECEPTOR IN CONTROL OF ESTRAIDOL HORMONES SECRETION DURING PROESTRUS PHASE IN FEMALE RATS,” JOURNAL OF VETERINARY RESEARCH, vol. 61, no. 3, pp. 273–276, 2006, [Online]. Available: https://sid.ir/paper/35272/en

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