PATHOLOGICAL STUDY OF METHYLENE IMMINE IN THE LUNG OF CALVES

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SASANI F.; NAGHSHINEH R.

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Journal: Journal of Veterinary Research Year:2002 | Volume:57 | Issue:1 Page(s): 93-95

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Information Journal Paper

Title

PATHOLOGICAL STUDY OF METHYLENE IMMINE IN THE LUNG OF CALVES

Author(s)

SASANI F. | NAGHSHINEH R. | Issue Writer Certificate

Keywords

CALVESQ3

LUNGQ3

PATHOLOGYQ3

METHYLEN IMMINEQ4

3MIQ4

EDEMAQ3

EMPHYSEMAQ4

Abstract

Objective: Oral administration of L- tryptophan with a toxic effect produces acute bovine pulmonary EDEMA and EMPHYSEMA.In rumen tryptophan is metabolized to indole acetic acid and then by lactobacilli it will be changed to 3-methyI indole.Design: Interventional study.Animals: 4 CALVES (one calf tryptophan, 3 CALVES 3MI) and 2 CALVES for controls.Procedure: Experimentally, 0.64 gr/kg BW of tryptophan tablets were orally administrated to one male calf of 6 month of age, and 3 CALVES, were received 100, 150 mg/kg of 3MI orally respectively.Statistical analysis: Descriptive statistics.Results: After 4 days all CALVES were affected by ARDS dyspnea with oral and nasal discharge and tachypnea.Conclusion: Pathophysiologic mechanism of EDEMA is related to increasing endothelial and alveolar permeability due to the injury of endothelial cells, type I pneumonocyte and clara cells. The important role is cytochrome dependent-mixed function oxidase (MFO) activity and delivery of METHYLEN IMMINE a kind of free radical. The nucleophilic material like GSH, L- cysteine and N- acetyl L cysteine, prevent covalent combination of reactive metabolite of 3MI to microsomal proteins. Some other substances like Phenobarbital which induces cytochrome P-450, would be able to evacuate 3MI from plasma and therefore prevents the pulmonary tissue from injury.

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APA: Copy

SASANI, F., & NAGHSHINEH, R.. (2002). PATHOLOGICAL STUDY OF METHYLENE IMMINE IN THE LUNG OF CALVES. JOURNAL OF VETERINARY RESEARCH, 57(1), 93-95. SID. https://sid.ir/paper/35367/en

Vancouver: Copy

SASANI F., NAGHSHINEH R.. PATHOLOGICAL STUDY OF METHYLENE IMMINE IN THE LUNG OF CALVES. JOURNAL OF VETERINARY RESEARCH[Internet]. 2002;57(1):93-95. Available from: https://sid.ir/paper/35367/en

IEEE: Copy

F. SASANI, and R. NAGHSHINEH, “PATHOLOGICAL STUDY OF METHYLENE IMMINE IN THE LUNG OF CALVES,” JOURNAL OF VETERINARY RESEARCH, vol. 57, no. 1, pp. 93–95, 2002, [Online]. Available: https://sid.ir/paper/35367/en

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