A PATHOLOGICAL STUDY OF HEPATIC LESIONS AFTER EXPERIMENTAL AFLATOXICOSIS IN BROILER CHICKENS

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SAFAMEHER A.R.; ASHRAFI HALAN J.; ALAMEH A.A.; SHIVAZAD M.

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Journal: Journal of Veterinary Research Year:2005 | Volume:60 | Issue:3 Page(s): 253-257

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Information Journal Paper

Title

A PATHOLOGICAL STUDY OF HEPATIC LESIONS AFTER EXPERIMENTAL AFLATOXICOSIS IN BROILER CHICKENS

Author(s)

SAFAMEHER A.R. | ASHRAFI HALAN J. | ALAMEH A.A. | SHIVAZAD M. | Issue Writer Certificate

Keywords

AFLATOXICOSISQ4

LIVERQ2

CHICKENQ2

Abstract

Objective: To study gross and histopathologic lesions and also relative weight of LIVER in experimental AFLATOXICOSIS in Ross broiler chicks.Design: Experimental studyAnimals: Two hundred and forty 1-day-old Ross broiler CHICKEN.Statistic analysis: Linear model analysis and Duncan's method for mean values with SAS package.Procedure: The CHICKENs were fed by NRC (1994) diet.Feed and water were provided ad libitum. The diets were divided into 3 groups: control (0 or basal) and treatment with 1 and 2 ppm of aflatoxin. Aflatoxin was produced by infecting of autoclaved rice with Aspergillus parasiticus NRRL-2999 in the flasks and titrated by TLC and HPLC. After 21 and 42 days, three CHICKENs from each group randomly killed and their LIVERs were weighed. Tissue samples were collected and fixed in 10% neutral buffered formalin, embedded in paraffin, sectioned at 5 !lm and stained by haematoxylin and eosin (H&E). Results: Relative weights of the LIVERs (g/100g.b.w) in treatment groups were significantly increased as compared with control (p<0.05). Histopathologic examination revealed severe fatty change, regeneration foci of LIVER cells, fibrosis of portal regions and bile ductile hyperplasia. The lesions were very severe in 42-days-old CHICKENs and had the lesser severity in 21-days-old CHICKENs.Conclusion: LIVER is the target organ for aflatoxin.Aflatoxin causes severe lesions in the LIVER and increase its relative weight. Prolonged exposure to low concentrations of toxin produces severe changes in fat metabolism and bile ductules proliferation.

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APA: Copy

SAFAMEHER, A.R., ASHRAFI HALAN, J., ALAMEH, A.A., & SHIVAZAD, M.. (2005). A PATHOLOGICAL STUDY OF HEPATIC LESIONS AFTER EXPERIMENTAL AFLATOXICOSIS IN BROILER CHICKENS. JOURNAL OF VETERINARY RESEARCH, 60(3), 253-257. SID. https://sid.ir/paper/35589/en

Vancouver: Copy

SAFAMEHER A.R., ASHRAFI HALAN J., ALAMEH A.A., SHIVAZAD M.. A PATHOLOGICAL STUDY OF HEPATIC LESIONS AFTER EXPERIMENTAL AFLATOXICOSIS IN BROILER CHICKENS. JOURNAL OF VETERINARY RESEARCH[Internet]. 2005;60(3):253-257. Available from: https://sid.ir/paper/35589/en

IEEE: Copy

A.R. SAFAMEHER, J. ASHRAFI HALAN, A.A. ALAMEH, and M. SHIVAZAD, “A PATHOLOGICAL STUDY OF HEPATIC LESIONS AFTER EXPERIMENTAL AFLATOXICOSIS IN BROILER CHICKENS,” JOURNAL OF VETERINARY RESEARCH, vol. 60, no. 3, pp. 253–257, 2005, [Online]. Available: https://sid.ir/paper/35589/en

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