Investigation the Effect of tamoxifen on CTNNBIP1 in cancer stem cells derived from MKN-45 cell line

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ghodrati B.; AKRAMI H.

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ISSN: 2588-4824

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Journal: JOURNAL OF CELL & TISSUE Year:2019 | Volume:10 | Issue:1 Page(s): 42-53

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Title

Investigation the Effect of tamoxifen on CTNNBIP1 in cancer stem cells derived from MKN-45 cell line

Author(s)

ghodrati B. | AKRAMI H. | Issue Writer Certificate

Keywords

gastric cancerQ1

cancer stem cellsQ1

tamoxifenQ2

Wnt / β-catenin signal pathwayQ1

CTNNBIP1 geneQ1

Abstract

Aim: In the current study, effect of various concentrations of tamoxifen on CTNNBIP1 expression gene in the cancer cells derived from MKN-45 cell line of gastric cancer was considered as a therapeutic potential. Materials and method: The CSCs derived from the MKN-45 cell line were treated with different concentrations of tamoxifen for 48 hours and then cell survival was evaluated by the Trypan Blue test. After obtaining IC50, we examined the effect of 100 µ M tamoxifen on the expression of CTNNBIP1 in CSCs as a therapeutic potential. Results: Analysis of Real-time RT-PCR data showed that 100 μ M tamoxifen in a 48-houred treatment can increase the expression of CTNNBIP1 gene. Conclusions: According to the results, it was concluded that tamoxifen has an inhibitory effect on the Wnt signal pathway and beta-catenin protein by increasing the expression of the CTNNBIP1 gene.

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APA: Copy

ghodrati, B., & AKRAMI, H.. (2019). Investigation the Effect of tamoxifen on CTNNBIP1 in cancer stem cells derived from MKN-45 cell line. JOURNAL OF CELL & TISSUE, 10(1 ), 42-53. SID. https://sid.ir/paper/360431/en

Vancouver: Copy

ghodrati B., AKRAMI H.. Investigation the Effect of tamoxifen on CTNNBIP1 in cancer stem cells derived from MKN-45 cell line. JOURNAL OF CELL & TISSUE[Internet]. 2019;10(1 ):42-53. Available from: https://sid.ir/paper/360431/en

IEEE: Copy

B. ghodrati, and H. AKRAMI, “Investigation the Effect of tamoxifen on CTNNBIP1 in cancer stem cells derived from MKN-45 cell line,” JOURNAL OF CELL & TISSUE, vol. 10, no. 1 , pp. 42–53, 2019, [Online]. Available: https://sid.ir/paper/360431/en

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