Effects of Cholestasis on Aquaporin 4 Choroid Plexus of Male Wistar Rat

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ORYAN SH.; NABIUNI M.; Eslimi Esfahani D.

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ISSN: 2588-4824

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Journal: Journal of Animal Research Year:2017 | Volume:30 | Issue:1 Page(s): 0-0

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Title

Effects of Cholestasis on Aquaporin 4 Choroid Plexus of Male Wistar Rat

Author(s)

ORYAN SH. | NABIUNI M. | Eslimi Esfahani D. | Issue Writer Certificate

Keywords

CholestasisQ1

Aquaporin-4Q2

Hepatic EncephalopathyQ1

Choroid PlexusQ1

Abstract

Liver failure and Cholestasis are associated with progressive brain edema (astrocyte swelling), which underlies Hepatic Encephalopathy (HE). Aquaporin4 (AQP4) is the main water channel in the brain that has important role in water transport across bloodbrain-barrier. It has been proved that intracranial pressure and also expression of AQP4 increase in brain edema. The aim of this study was to determine whether edema of Cholestasis is associated with the brain Aquaporin-4 (AQP4). Data assessedby analysis of variance (ANOVA) followed by post-hoc Tukey test. Male wistar rats (n = 30) were divided into three groups as control (nosurgery), sham (surgery without bile duct ligation) and cholestatic (surgery with bile duct ligation, BDL). After 2 weeks, expression of AQP4 in control, sham, and experimental groups were determinedby immunohistochemistry. AQP4 expression was significantly increased in BDL (p <0. 05), but not incontrol and sham groups (P<0. 05). Increased brain water was observed in Cholestasis compared to sham and control rats (P<0. 05). These results indicate that increased AQP4 levels in Choroid Plexus in response to brain injury are likely critical to the development of brain oedema in Cholestasis.

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APA: Copy

ORYAN, SH., NABIUNI, M., & Eslimi Esfahani, D.. (2017). Effects of Cholestasis on Aquaporin 4 Choroid Plexus of Male Wistar Rat. JOURNAL OF ANIMAL RESEARCH (IRANIAN JOURNAL OF BIOLOGY), 30(1 ), 0-0. SID. https://sid.ir/paper/366294/en

Vancouver: Copy

ORYAN SH., NABIUNI M., Eslimi Esfahani D.. Effects of Cholestasis on Aquaporin 4 Choroid Plexus of Male Wistar Rat. JOURNAL OF ANIMAL RESEARCH (IRANIAN JOURNAL OF BIOLOGY)[Internet]. 2017;30(1 ):0-0. Available from: https://sid.ir/paper/366294/en

IEEE: Copy

SH. ORYAN, M. NABIUNI, and D. Eslimi Esfahani, “Effects of Cholestasis on Aquaporin 4 Choroid Plexus of Male Wistar Rat,” JOURNAL OF ANIMAL RESEARCH (IRANIAN JOURNAL OF BIOLOGY), vol. 30, no. 1 , pp. 0–0, 2017, [Online]. Available: https://sid.ir/paper/366294/en

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