Evaluation of Sperm Quality and Oxidative Stress Level in Asthenoteratozoospermia Men by N-Acetylcysteine Treatment

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Jannatifar r.; PARIVAR K.; NASR ESFAHANI M.H.; HAYATI ROODBARI N.

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Journal: JOURNAL OF ANIMAL PHYSIOLOGY AND DEVELOPMENT (QUARTERLY JOURNAL OF BIOLOGICAL SCIENCES) Year:2020 | Volume:13 | Issue:2 (49) Page(s): 27-38

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Title

Evaluation of Sperm Quality and Oxidative Stress Level in Asthenoteratozoospermia Men by N-Acetylcysteine Treatment

Author(s)

Jannatifar r. | PARIVAR K. | NASR ESFAHANI M.H. | HAYATI ROODBARI N. | Issue Writer Certificate

Keywords

InfertilityQ2

N-Acetyl-CysteineQ1

Oxidative StressQ1

AsthenoteratozoospermiaQ1

Abstract

Inroduction & Objective: Infertile men have higher levels of semen reactive oxygen species (ROS) than fertile men. High levels of semen ROS can cause sperm dysfunction, sperm DNA damage and reduced male reproductive potential. This study investigated the effects of supplementation with N-Acetyl-Cysteine (NAC) on sperm parameters; chromatin integrity and level of stress oxidative (ROS) in infertile men. Material and Methods: The study was carried out in the unit of ACECR Infertility Research Center, Qom, Iran. The patients consisted of 50 infertile men with Asthenoteratozoospermia who received NAC (600 mg/d) orally for 3 months, after which they were compared with pre-treatment status. Sperm parameters according WHO (World Health Organization) guidelines, protamine deficiency (chromomycin A3 staining), sperm DNA damage (TUNEL assay), percentage and intensity of ROS (DCFH-DA staining) were assessed in infertile men. Results: After NAC treatment, patients' sperm parameters improved (P<0. 05). DNA fragmentation and protamine deficiency showed significant decreases compared to pre-treatment levels (P<0. 05). Hormonal profile improvement was associated with lowered FSH and LH levels and increased amount of testosterone (P<0. 05). Stress oxidative level (ROS) significantly decreased (P<0. 05). The correlation between Stress oxidative and sperm parameters was found (P<0. 05). Conclusion: NAC oral supplementation may improve sperm parameters and oxidative/antioxidant status in infertile males.

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APA: Copy

Jannatifar, r., PARIVAR, K., NASR ESFAHANI, M.H., & HAYATI ROODBARI, N.. (2020). Evaluation of Sperm Quality and Oxidative Stress Level in Asthenoteratozoospermia Men by N-Acetylcysteine Treatment. JOURNAL OF ANIMAL PHYSIOLOGY AND DEVELOPMENT (QUARTERLY JOURNAL OF BIOLOGICAL SCIENCES), 13(2 (49) ), 27-38. SID. https://sid.ir/paper/375316/en

Vancouver: Copy

Jannatifar r., PARIVAR K., NASR ESFAHANI M.H., HAYATI ROODBARI N.. Evaluation of Sperm Quality and Oxidative Stress Level in Asthenoteratozoospermia Men by N-Acetylcysteine Treatment. JOURNAL OF ANIMAL PHYSIOLOGY AND DEVELOPMENT (QUARTERLY JOURNAL OF BIOLOGICAL SCIENCES)[Internet]. 2020;13(2 (49) ):27-38. Available from: https://sid.ir/paper/375316/en

IEEE: Copy

r. Jannatifar, K. PARIVAR, M.H. NASR ESFAHANI, and N. HAYATI ROODBARI, “Evaluation of Sperm Quality and Oxidative Stress Level in Asthenoteratozoospermia Men by N-Acetylcysteine Treatment,” JOURNAL OF ANIMAL PHYSIOLOGY AND DEVELOPMENT (QUARTERLY JOURNAL OF BIOLOGICAL SCIENCES), vol. 13, no. 2 (49) , pp. 27–38, 2020, [Online]. Available: https://sid.ir/paper/375316/en

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