Effect of Green Tea Extract (Camellia sinensis) on Levels of Sex Hormones in Letrozole-Induced Polycystic Ovary Syndrome (PCOS) in Adult Female Wistar Rats

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Khodarahmi S.E.; EIDI A.; MORTAZAVI P.

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Journal: JOURNAL OF ANIMAL PHYSIOLOGY AND DEVELOPMENT (QUARTERLY JOURNAL OF BIOLOGICAL SCIENCES) Year:2020 | Volume:13 | Issue:2 (49) Page(s): 51-59

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Title

Effect of Green Tea Extract (Camellia sinensis) on Levels of Sex Hormones in Letrozole-Induced Polycystic Ovary Syndrome (PCOS) in Adult Female Wistar Rats

Author(s)

Khodarahmi S.E. | EIDI A. | MORTAZAVI P. | Issue Writer Certificate

Keywords

Green TeaQ1

Camellia sinensisQ1

LetrozoleQ1

Polycystic Ovarian SyndromeQ2

RatQ2

Abstract

Inroduction & Objective: Green Tea (Camellia sinensis) was considered effective medicine for treating different ailments in ancient Asian folk medicine. It is known for its abundance of antioxidants. Polycystic ovary syndrome (PCOS) is a prevalent endocrinological disorder in reproductive-age women and is often associated with metabolic syndrome. The purpose of the study, the effect of Green Tea extract on Letrozoleinduced oxidative stress was investigated on levels of sex hormones of adult female Wistar Rats. Material and Methods: In this study, a total of 48 female Rats were randomly divided into 8 groups of 6: The normal control group (intact), the healthy experimental group (Green Tea extract 50, 100 and 200 mg/kg bw, gavage), PCOS control group (Letrozole 1 mg/kg bw, gavage), PCOS experimental group (Green Tea extract 50, 100 and 200 mg/kg bw together Letrozole). The animals were euthanized 24 h after the last dose of the treatment on day 29. Blood was immediately obtained after the animals were sacrificed. The serum was used to assay the levels of testosterone, estradiol, FSH and LH. Results: Our results showed that administRation of Letrozole significantly increased the levels of testosterone, estradiol, LH and decreased FSH. The results study showed that Green Tea extract treatment significantly decreased the levels of testosterone, estradiol, LH and increased FSH in PCOS experimental group. Conclusion: These results provide data supporting the potential clinical use of Green Tea extract for the treatment of PCOS.

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APA: Copy

Khodarahmi, S.E., EIDI, A., & MORTAZAVI, P.. (2020). Effect of Green Tea Extract (Camellia sinensis) on Levels of Sex Hormones in Letrozole-Induced Polycystic Ovary Syndrome (PCOS) in Adult Female Wistar Rats. JOURNAL OF ANIMAL PHYSIOLOGY AND DEVELOPMENT (QUARTERLY JOURNAL OF BIOLOGICAL SCIENCES), 13(2 (49) ), 51-59. SID. https://sid.ir/paper/376931/en

Vancouver: Copy

Khodarahmi S.E., EIDI A., MORTAZAVI P.. Effect of Green Tea Extract (Camellia sinensis) on Levels of Sex Hormones in Letrozole-Induced Polycystic Ovary Syndrome (PCOS) in Adult Female Wistar Rats. JOURNAL OF ANIMAL PHYSIOLOGY AND DEVELOPMENT (QUARTERLY JOURNAL OF BIOLOGICAL SCIENCES)[Internet]. 2020;13(2 (49) ):51-59. Available from: https://sid.ir/paper/376931/en

IEEE: Copy

S.E. Khodarahmi, A. EIDI, and P. MORTAZAVI, “Effect of Green Tea Extract (Camellia sinensis) on Levels of Sex Hormones in Letrozole-Induced Polycystic Ovary Syndrome (PCOS) in Adult Female Wistar Rats,” JOURNAL OF ANIMAL PHYSIOLOGY AND DEVELOPMENT (QUARTERLY JOURNAL OF BIOLOGICAL SCIENCES), vol. 13, no. 2 (49) , pp. 51–59, 2020, [Online]. Available: https://sid.ir/paper/376931/en

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