Hyperbranched polymers functionalized magnetic nanoparticles for targeted delivery and intracellular release of cisplatin

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TABATABAEI REZAEI SEYED JAMAL; MASHHADI MALEKZADEH ASEMEH; Sarbaz Laila; NIKNEJAD HASSAN; RAMAZANI ALI

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Journal: Applied Chemistry Today Year:2020 | Volume:15 | Issue:54 Page(s): 55-69

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Title

Hyperbranched polymers functionalized magnetic nanoparticles for targeted delivery and intracellular release of cisplatin

Author(s)

Keywords

magnetic nanoparticlesQ1

Hyperbranched polymersQ1

Targeted drug deliveryQ1

CisplatinQ1

Controlled releaseQ2

Abstract

To address the obstacles facing the clinical use of Cisplatin (cis-diamminedichloroplatinum(II) (CDDP)), including poor bioavailability, severe dose-limiting side effects and rapid development of drug resistance, a novel pH-sensitive superparamagnetic drug delivery system was developed based on hyperbranched poly(ethylene glycol-b-citric acid) modified Fe3O4 nanoparticles (Fe3O4@PCA-b-PEG) for targeted delivery and pH-triggered intracellular release of Cisplatin. The Fe3O4@PCA(CDDP)-b-PEG nanoparticles exhibit excellent water dispersity with well-defined size distribution (around 49. 5 nm) and strong magnetisability. In vitro release experiments revealed that the CDDP-loaded delivery system is relatively stable at physiologic conditions (pH 7. 4 and 37 ˚ C) but susceptible to acidic environments (pH 5. 3 and 37 ˚ C) which would trigger the release of loaded drugs. Fluorescent microscope studies revealed that the Fe3O4@PCA(CDDP)-b-PEG nanoparticles could be efficiently accumulate in tumor tissue. Also, in comparison with CDDP, the Fe3O4@PCA(CDDP)-b-PEG exert higher cytotoxicity towards the human cervical cancer HeLa cells and the Human breast cancer MDA-MB-231 cells. The results indicate that the prepared superparamagnetic Fe3O4@PCA(CDDP)-b-PEG nanoparticles are a promising candidate for inhibiting proliferation of cancer cells.

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APA: Copy

TABATABAEI REZAEI, SEYED JAMAL, MASHHADI MALEKZADEH, ASEMEH, Sarbaz, Laila, NIKNEJAD, HASSAN, & RAMAZANI, ALI. (2020). Hyperbranched polymers functionalized magnetic nanoparticles for targeted delivery and intracellular release of cisplatin. JOURNAL OF APPLIED CHEMISTRY, 15(54 ), 55-69. SID. https://sid.ir/paper/383348/en

Vancouver: Copy

TABATABAEI REZAEI SEYED JAMAL, MASHHADI MALEKZADEH ASEMEH, Sarbaz Laila, NIKNEJAD HASSAN, RAMAZANI ALI. Hyperbranched polymers functionalized magnetic nanoparticles for targeted delivery and intracellular release of cisplatin. JOURNAL OF APPLIED CHEMISTRY[Internet]. 2020;15(54 ):55-69. Available from: https://sid.ir/paper/383348/en

IEEE: Copy

SEYED JAMAL TABATABAEI REZAEI, ASEMEH MASHHADI MALEKZADEH, Laila Sarbaz, HASSAN NIKNEJAD, and ALI RAMAZANI, “Hyperbranched polymers functionalized magnetic nanoparticles for targeted delivery and intracellular release of cisplatin,” JOURNAL OF APPLIED CHEMISTRY, vol. 15, no. 54 , pp. 55–69, 2020, [Online]. Available: https://sid.ir/paper/383348/en

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