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Information Journal Paper

Title

Leukocyte Cross-Match Results after Lymphocyte Immunization in Women with Recurrent Spontaneous Abortion

Pages

  19-23

Abstract

 Aims The normal architecture of bone marrow apparently is simple; however, there is an important feature that immature elements of bone marrow are never seen in peripheral blood of normal subjects and we can find these elements only in special conditions such as metastasis or leukemia. The aim of this study was to investigate the physical structure of bone marrow regarding fractal model and diffusion limited growth phenomenon. Materials & Methods This descriptive and cross-sectional study was conducted on 704 volunteer subjects with RSA history referred to Sarem women’ s hospital (Tehran, Iran) from 2009 to 2013. The peripheral blood mononuclear cells (PBMCs) were isolated from their husband or a third donor and were injected into the patients, two or three times. Two weeks after the last immunization, the patients’ sera were tested for anti-paternal cytotoxic antibodies (APCAs) by leukocyte cross-match test. The leukocyte cross-match percentages were considered as positive if its values were more than 35% and vice versa. Findings A positive result of leukocyte cross-match test was found in 319 (45. 31%) patients with RSA that received paternal PBMCs two times. Immunization was repeated for the patients with negative tests using paternal or third donor PBMCs and positive result were observed in 219 (31. 11%) patients. Totally, positive results were found in 538 (76. 42%) patients. Conclusion Lymphocyte therapy can enhances the production of APCAs in patients with RSA. It can increase the possibility of positive cross match test in these patients when it is repeated for three times.

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    APA: Copy

    SAREMI, A.T., Sanaye Naderi, M., POOLADI, A., YOUNESI, B., LASHGARI, P., & ZARE, A.. (2018). Leukocyte Cross-Match Results after Lymphocyte Immunization in Women with Recurrent Spontaneous Abortion. SAREM JOURNAL OF MEDICAL RESEARCH (SAREM JOURNAL OF REPRODUCTIVE MEDICINE), 2(4 ), 19-23. SID. https://sid.ir/paper/383544/en

    Vancouver: Copy

    SAREMI A.T., Sanaye Naderi M., POOLADI A., YOUNESI B., LASHGARI P., ZARE A.. Leukocyte Cross-Match Results after Lymphocyte Immunization in Women with Recurrent Spontaneous Abortion. SAREM JOURNAL OF MEDICAL RESEARCH (SAREM JOURNAL OF REPRODUCTIVE MEDICINE)[Internet]. 2018;2(4 ):19-23. Available from: https://sid.ir/paper/383544/en

    IEEE: Copy

    A.T. SAREMI, M. Sanaye Naderi, A. POOLADI, B. YOUNESI, P. LASHGARI, and A. ZARE, “Leukocyte Cross-Match Results after Lymphocyte Immunization in Women with Recurrent Spontaneous Abortion,” SAREM JOURNAL OF MEDICAL RESEARCH (SAREM JOURNAL OF REPRODUCTIVE MEDICINE), vol. 2, no. 4 , pp. 19–23, 2018, [Online]. Available: https://sid.ir/paper/383544/en

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