Synthesis of new dipeptides based on uracil and thymine and investigation of the molecular docking of these compounds as inhibitors of quorum sensing system in Pseudomonas aeruginosa

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Heidari Azam; Valikhani Fard Nazila; Noshiranzadeh Nader; bikas Rahman

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Journal: JOURNAL OF APPLIED CHEMISTRY Year:2019 | Volume:14 | Issue:50 Page(s): 279-292

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Title

Synthesis of new dipeptides based on uracil and thymine and investigation of the molecular docking of these compounds as inhibitors of quorum sensing system in Pseudomonas aeruginosa

Author(s)

Heidari Azam | Valikhani Fard Nazila | Noshiranzadeh Nader | bikas Rahman | Issue Writer Certificate

Keywords

dipeptideQ1

SynthesisQ2

thymineQ2

uracilQ1

Molecular dockingQ1

quorum sensingQ1

Abstract

In this study, due to the importance of dipeptide compounds in diagnosis of disease or as drug compounds, new dipeptide compounds were synthesized using pyrimidine derivatives of thymine and uracil. The reaction of Methyl 2-(5-methyl-2, 4-dioxo-4, 3-dihydropyrimidine-1 (2 H)-yl) acetate and methyl 2-2, 4-dioxo-4, 3-dihydropyrimidine-1 (2H)-Il) acetate with diamine derivatives lead to the production of dipeptide derivatives in good yield. Then, using the computational design of the drug by the Molecular docking method, the inhibitory effect of synthetic compounds on the LasR regulatory protein of Pseudomonas aeruginosa quorum sensing system, which plays an important role in regulating the expression of pathogenic genes in bacteria, were investigated. The results of the study showed that synthetic compounds have a significant inhibitory effect on the LasR protein.

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APA: Copy

Heidari, Azam, Valikhani Fard, Nazila, Noshiranzadeh, Nader, & bikas, Rahman. (2019). Synthesis of new dipeptides based on uracil and thymine and investigation of the molecular docking of these compounds as inhibitors of quorum sensing system in Pseudomonas aeruginosa. JOURNAL OF APPLIED CHEMISTRY, 14(50 ), 279-292. SID. https://sid.ir/paper/383984/en

Vancouver: Copy

Heidari Azam, Valikhani Fard Nazila, Noshiranzadeh Nader, bikas Rahman. Synthesis of new dipeptides based on uracil and thymine and investigation of the molecular docking of these compounds as inhibitors of quorum sensing system in Pseudomonas aeruginosa. JOURNAL OF APPLIED CHEMISTRY[Internet]. 2019;14(50 ):279-292. Available from: https://sid.ir/paper/383984/en

IEEE: Copy

Azam Heidari, Nazila Valikhani Fard, Nader Noshiranzadeh, and Rahman bikas, “Synthesis of new dipeptides based on uracil and thymine and investigation of the molecular docking of these compounds as inhibitors of quorum sensing system in Pseudomonas aeruginosa,” JOURNAL OF APPLIED CHEMISTRY, vol. 14, no. 50 , pp. 279–292, 2019, [Online]. Available: https://sid.ir/paper/383984/en

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