Effects of selenium nanoparticles on stearoyl-CoA desaturase gene transcription rate in adipose tissue of prepubertal male lambs

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Esmaeeli Najafabadi H.; KOJOURI GH.A.; AHADI A.M.

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Journal: VETERINARY CLINICAL PATHOLOGY (VETERINARY JOURNAL TABRIZ) Year:2020 | Volume:14 | Issue:1 (53) Page(s): 73-83

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Title

Effects of selenium nanoparticles on stearoyl-CoA desaturase gene transcription rate in adipose tissue of prepubertal male lambs

Author(s)

Esmaeeli Najafabadi H. | KOJOURI GH.A. | AHADI A.M. | Issue Writer Certificate

Keywords

Selenium nanoparticlesQ1

Stearoyl CoA enzymeQ1

Tail fat tissueQ1

LambQ1

Abstract

Selenium plays a crucial role in the formation of selenoprotein and hormones. The stearoyl-CoA desaturase enzyme (SCD) is present in many tissues of the body and its activity leads to the formation of a single-stranded fatty acid from saturated fatty acids. The present study was carried out on fat tail weaning male Lambs to evaluate the effect of oral Selenium nanoparticles administration on tail fat transcription rate of stearoyl-CoA desaturase enzyme. For this purpose, 14 male Lambs were selected at weaning time and divided into three groups: treatment 1 (5 Lambs), treatment 2 (5 Lambs) and control (4 Lambs). Selenium nanoparticles were administered for 20 consecutive days at a dose of 0. 05 and 0. 1 mg/kg to treatment groups 1 and 2, respectively and distilled water to the control ones. Tail fat tissue samples were collected at days 0, 20 and 30 via core biopsy needle. Transcription rate of stearoyl-CoA desaturase (SCD) enzyme gene was determined by RT-PCR method and data were analyzed statistically using ANOVA test at the level of p<0. 05. Due to obtained results the transcription rate of SCD gene in treatment group 2 was significantly higher than that in group 1 at day 20. According to the results, oral supplementation of Selenium nanoparticles at dose of 0. 1 mg/kg for 20 days, increased the transcription rate of SCD gene and enhanced the quality of fatty acids of weaning Lambs. These findings explain the beneficial effects of Se-NPs on unsaturated fatty acid formation for the first time.

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APA: Copy

Esmaeeli Najafabadi, H., KOJOURI, GH.A., & AHADI, A.M.. (2020). Effects of selenium nanoparticles on stearoyl-CoA desaturase gene transcription rate in adipose tissue of prepubertal male lambs. VETERINARY CLINICAL PATHOLOGY (VETERINARY JOURNAL TABRIZ), 14(1 (53) ), 73-83. SID. https://sid.ir/paper/391424/en

Vancouver: Copy

Esmaeeli Najafabadi H., KOJOURI GH.A., AHADI A.M.. Effects of selenium nanoparticles on stearoyl-CoA desaturase gene transcription rate in adipose tissue of prepubertal male lambs. VETERINARY CLINICAL PATHOLOGY (VETERINARY JOURNAL TABRIZ)[Internet]. 2020;14(1 (53) ):73-83. Available from: https://sid.ir/paper/391424/en

IEEE: Copy

H. Esmaeeli Najafabadi, GH.A. KOJOURI, and A.M. AHADI, “Effects of selenium nanoparticles on stearoyl-CoA desaturase gene transcription rate in adipose tissue of prepubertal male lambs,” VETERINARY CLINICAL PATHOLOGY (VETERINARY JOURNAL TABRIZ), vol. 14, no. 1 (53) , pp. 73–83, 2020, [Online]. Available: https://sid.ir/paper/391424/en

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