Protective Effect of Camel Milk on Gentamicin-inducedNephrotoxicity: From Renal Biomarkers to Histopathology Evidence

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Arab Fereshteh; Naeimi Saeideh; JAVAHERI VAYEGHAN ABBAS; MUHAMMADNEJAD AHAD; AHMADI HAMEDANI MAHMOOD

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Journal: Iranian Journal of Veterinary Medicine Year:2021 | Volume:15 | Issue:1 Page(s): 79-92

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Title

Protective Effect of Camel Milk on Gentamicin-inducedNephrotoxicity: From Renal Biomarkers to Histopathology Evidence

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Keywords

Camel milkQ1

GentamicinQ1

NephrotoxicityQ1

Oxidative StressQ1

RatQ3

Abstract

BACKGROUND: Gentamicin is an effective antibiotic with some important side effects, such as Nephrotoxicity. There is evidence of renoprotective effects and antioxidant properties for Camel milk. OBJECTIVES: In this study, the impact of Camel milk on the Nephrotoxicity induced by Gentamicin was evaluated. METHODS: The present study was performed on four groups of six Wistar Rats. Group 1(C), as the control group, received exclusively normal saline injections and the Rats in group 2 (GM) received intraperitoneal Gentamicin injections at the dose of 100 mg/kg for the last ten days. The animals in group 3 (CM) were fed by 5 mL/Rat/day of Camel milk through gavage for 15 days. Group 4 (MGM) was fed Camel milk only for the first five days followed by Gentamicin injections for 10 days. Serum urea, creatinine, and superoxide dismutase (SOD) were measured and kidneys were studied histopathologically. RESULTS: Increased concentRations of urea and creatinine along with the decreased level of SOD were found in the GM group. Histopathologic changes, such as eosinophilic casts in the tubular lumen, capillary congestion, glomerulonephritis, necrosis, interstitial nephritis, and edema were more common in the GM group, in comparison with the C, CM, and MGM groups (P<0. 05). The elevations in serum urea and creatinine (P<0. 05) were significantly prevented by the co-administra-tion of Camel milk and Gentamicin. Moreover, a significant increase in the serum activity of SOD was revealed in the GM group (P<0. 05). Camel milk significantly prevented tissue injury, in comparison with the GM group (P<0. 05). CONCLUSIONS: Our results demonstRated that Gentamicin-induced histological and biochemical alteRations in the kid-ney decreased significantly due to Camel milk consumption.

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APA: Copy

Arab, Fereshteh, Naeimi, Saeideh, JAVAHERI VAYEGHAN, ABBAS, MUHAMMADNEJAD, AHAD, & AHMADI HAMEDANI, MAHMOOD. (2021). Protective Effect of Camel Milk on Gentamicin-inducedNephrotoxicity: From Renal Biomarkers to Histopathology Evidence. IRANIAN JOURNAL OF VETERINARY MEDICINE (INTERNATIONAL JOURNAL OF VETERINARY RESEARCH), 15(1 ), 79-92. SID. https://sid.ir/paper/397033/en

Vancouver: Copy

Arab Fereshteh, Naeimi Saeideh, JAVAHERI VAYEGHAN ABBAS, MUHAMMADNEJAD AHAD, AHMADI HAMEDANI MAHMOOD. Protective Effect of Camel Milk on Gentamicin-inducedNephrotoxicity: From Renal Biomarkers to Histopathology Evidence. IRANIAN JOURNAL OF VETERINARY MEDICINE (INTERNATIONAL JOURNAL OF VETERINARY RESEARCH)[Internet]. 2021;15(1 ):79-92. Available from: https://sid.ir/paper/397033/en

IEEE: Copy

Fereshteh Arab, Saeideh Naeimi, ABBAS JAVAHERI VAYEGHAN, AHAD MUHAMMADNEJAD, and MAHMOOD AHMADI HAMEDANI, “Protective Effect of Camel Milk on Gentamicin-inducedNephrotoxicity: From Renal Biomarkers to Histopathology Evidence,” IRANIAN JOURNAL OF VETERINARY MEDICINE (INTERNATIONAL JOURNAL OF VETERINARY RESEARCH), vol. 15, no. 1 , pp. 79–92, 2021, [Online]. Available: https://sid.ir/paper/397033/en

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