L-METHIONINE ATTENUATES GENTAMICIN NEPHROTOXICITY IN MALE WISTAR RAT: PATHOLOGICAL AND BIOCHEMICAL FINDINGS

Q: How can I download an article?

To download an article from SID, first log in to the site, search for the article title, and click on the 'Download Article' option.

Q: How can I download an ISI article?

To download an ISI article on SID, enter the keyword or article title in the search bar, view the relevant results, click on the desired article, and select the 'Download Article' option.

Q: How can I access the SID database?

To access the SID database, visit SID.ir, create an account, and log in to access scientific resources.

Q: Is downloading articles from SID free?

Some articles on SID are available for free, while others require payment. Details are specified on the article's page.

DERAKHSHANFAR AMIN; BIDADKOSH A.; HASHEMPOUR SADEGHIAN M.

مرکز اطلاعات علمی Scientific Information Database (SID) - Trusted Source for Research and Academic Resources

Journal Paper

Paper Information

Journal: IRANIAN JOURNAL OF VETERINARY RESEARCH (IJVR) Year:2009 | Volume:10 | Issue:4 (29) Page(s): 323-328

Download Full-Text

Persian Verion

View:

1,355

Download:

232

Cites:

Information Journal Paper

Title

L-METHIONINE ATTENUATES GENTAMICIN NEPHROTOXICITY IN MALE WISTAR RAT: PATHOLOGICAL AND BIOCHEMICAL FINDINGS

Author(s)

DERAKHSHANFAR AMIN | BIDADKOSH A. | HASHEMPOUR SADEGHIAN M. | Issue Writer Certificate

Keywords

GENTAMICINQ3

METHIONINEQ2

NEPHROTOXICITYQ3

Abstract

The clinical uses of GENTAMICIN have so far been restricted due to NEPHROTOXICITY and ototoxicity. The exact mechanism of NEPHROTOXICITY is still unknown; however, it appears that free radicals may be involved. METHIONINE has previously been shown to alleviate oxidative stress involved in ototoxicity due to its antioxidant properties. Therefore, the effect of METHIONINE supplementation on the GENTAMICIN induced NEPHROTOXICITY was examined in this study. Twenty eight male Wistar rats were randomly divided into 4 equal groups to receive a daily corresponding dose of either GENTAMICIN (80mg/kg B.W.; i.m.; group GN), L-methionine (100mg/kg B.W.; i.p.; MT), combination thereof (MG), and normal saline as control (CT). After slaughtering the animals on day 11, values of blood urea nitrogen (BUN), serum creatinine concentration (SCr), urinary gamma glutamyl transpeptidase (GGT) activity, and renal cortical reduced glutathione (GSH) contents with histopathologic investigations were measured. In group GN, biochemical profiles showed a remarkable increase in BUN, SCr and urinary GGT concentration, and depletion of renal cortical of GSH. In addition, histopathologic studies revealed severe acute tubular necrosis, congestion and hyaline casts, verifying GENTAMICIN-induced NEPHROTOXICITY. In group MG, only mild epithelial changes and renal congestion were prominent findings. Moreover, these changes in rats given the combined therapy (MG) were significantly less than those of group GN, thereby suggesting that supplemented L-methionine ameliorate GENTAMICIN NEPHROTOXICITY in rat. In group MT, only medullary congestion was seen without change in the biochemical factors as was in the CT group with normal kidney structure. Generally, results of this study showed that METHIONINE may significantly prevent GENTAMICIN NEPHROTOXICITY, removing the oxidative stress.

Cites

No record.

References

No record.

Cite

APA: Copy

DERAKHSHANFAR, AMIN, BIDADKOSH, A., & HASHEMPOUR SADEGHIAN, M.. (2009). L-METHIONINE ATTENUATES GENTAMICIN NEPHROTOXICITY IN MALE WISTAR RAT: PATHOLOGICAL AND BIOCHEMICAL FINDINGS. IRANIAN JOURNAL OF VETERINARY RESEARCH (IJVR), 10(4 (29)), 323-328. SID. https://sid.ir/paper/85705/en

Vancouver: Copy

DERAKHSHANFAR AMIN, BIDADKOSH A., HASHEMPOUR SADEGHIAN M.. L-METHIONINE ATTENUATES GENTAMICIN NEPHROTOXICITY IN MALE WISTAR RAT: PATHOLOGICAL AND BIOCHEMICAL FINDINGS. IRANIAN JOURNAL OF VETERINARY RESEARCH (IJVR)[Internet]. 2009;10(4 (29)):323-328. Available from: https://sid.ir/paper/85705/en

IEEE: Copy

AMIN DERAKHSHANFAR, A. BIDADKOSH, and M. HASHEMPOUR SADEGHIAN, “L-METHIONINE ATTENUATES GENTAMICIN NEPHROTOXICITY IN MALE WISTAR RAT: PATHOLOGICAL AND BIOCHEMICAL FINDINGS,” IRANIAN JOURNAL OF VETERINARY RESEARCH (IJVR), vol. 10, no. 4 (29), pp. 323–328, 2009, [Online]. Available: https://sid.ir/paper/85705/en

Related Journal Papers