HISTOPATHOLOGIC AND BIOCHEMICAL STUDY ON GENTAMICIN-INDUCED NEPHROTOXICITY IN DONKEY

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POURJAFAR MEHRDAD; DERAKHSHANFAR AMIN; ARABI N.; BIDADKOSH A.

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Journal: SCIENTIFIC-RESEARCH IRANIAN VETERINARY JOURNAL Year:2007 | Volume:3 | Issue:1 (14) Page(s): 21-27

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Title

HISTOPATHOLOGIC AND BIOCHEMICAL STUDY ON GENTAMICIN-INDUCED NEPHROTOXICITY IN DONKEY

Author(s)

POURJAFAR MEHRDAD | DERAKHSHANFAR AMIN | ARABI N. | BIDADKOSH A. | Issue Writer Certificate

Keywords

GENTAMICINQ3

DONKEYQ3

HISTOPATHOLOGICQ2

BIOCHEMICALQ2

Abstract

GENTAMICIN is one of the wide spectrum antibiotics, whose utility has been limited in human and animals due to related side effects such as nephrotoxicity and ototoxicity. In this research, twenty-one healthy female DONKEYs (2-3 years old) were randomly divided into 3 equal groups. Before the study, clinical examinations were done and blood and urine samples were taken in order to ensure about the health of the animals. Group one (control) received only normal saline. Group two and three received 6.6mg/kgb.w and 13.2mg/kgb.w GENTAMICIN (IM, daily), respectively for 15 days. At the end of the experiment, all animals were euthanized and blood and urine as well as kidney tissue samples were taken. Results showed abnormalities in blood and urine BIOCHEMICAL factors and kidney tissue of group 3 and HISTOPATHOLOGIC changes in group two. Considering the results of group 2 and 3 and comparing with the control, it could be concluded that renal effects of GENTAMICIN in DONKEYs are dependent on dose and and length of its administration. It seems that its HISTOPATHOLOGICal side effects appear prior to BIOCHEMICAL abnormalities and the utility of this drug should be taken cautiously.

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APA: Copy

POURJAFAR, MEHRDAD, DERAKHSHANFAR, AMIN, ARABI, N., & BIDADKOSH, A.. (2007). HISTOPATHOLOGIC AND BIOCHEMICAL STUDY ON GENTAMICIN-INDUCED NEPHROTOXICITY IN DONKEY. SCIENTIFIC-RESEARCH IRANIAN VETERINARY JOURNAL, 3(1 (14)), 21-27. SID. https://sid.ir/paper/97484/en

Vancouver: Copy

POURJAFAR MEHRDAD, DERAKHSHANFAR AMIN, ARABI N., BIDADKOSH A.. HISTOPATHOLOGIC AND BIOCHEMICAL STUDY ON GENTAMICIN-INDUCED NEPHROTOXICITY IN DONKEY. SCIENTIFIC-RESEARCH IRANIAN VETERINARY JOURNAL[Internet]. 2007;3(1 (14)):21-27. Available from: https://sid.ir/paper/97484/en

IEEE: Copy

MEHRDAD POURJAFAR, AMIN DERAKHSHANFAR, N. ARABI, and A. BIDADKOSH, “HISTOPATHOLOGIC AND BIOCHEMICAL STUDY ON GENTAMICIN-INDUCED NEPHROTOXICITY IN DONKEY,” SCIENTIFIC-RESEARCH IRANIAN VETERINARY JOURNAL, vol. 3, no. 1 (14), pp. 21–27, 2007, [Online]. Available: https://sid.ir/paper/97484/en

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