The effect of bioactive peptides mixture extracted from sardine on total antioxidant capacity of serum, lipid peroxidation and blood parameters in rats exposed to restraint stress

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HEYDARI SH.; hossein najdgerami e.; NIKOO M.

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Journal: Journal of Animal Research Year:2017 | Volume:30 | Issue:3 Page(s): 0-0

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Title

The effect of bioactive peptides mixture extracted from sardine on total antioxidant capacity of serum, lipid peroxidation and blood parameters in rats exposed to restraint stress

Author(s)

HEYDARI SH. | hossein najdgerami e. | NIKOO M. | Issue Writer Certificate

Keywords

Bioactive peptidesQ1

SardineQ1

fluoxetineQ1

antioxidantQ1

immune systemQ1

restrained stressQ1

Abstract

Todays, chemical drugs such as fluoxetine with different side effects are used to reduce stress effects. In the current study, the effects of Bioactive peptides from fermented Sardine fish mixture on the total antioxidant capacity (TAC) and lipid peroxidation (MDA) of plasma and blood parameters as well was investigated in comparison with fluoxetine in restrained male rat. Thirty healthy male rats (100 ± 20 g) were randomly distributed in 6 cages at a density of 5 rat/cage and treated experimental groups (Control C, 2 hours restrained per day S, Bioactive peptides P, fluoxetine F, S+F, S+P. After 21 days, the results indicated that the lowest TAC and highest MDA was observes in restrained rats than control and S+P (P<0. 05) whereas no significant difference was seen between control, S+F and S+P (P>0. 05). The red blood cells, hematocrit and hemoglobin significantly increased in restrained rats than control and S+P (P<0. 05). The cellular immunity was affected by restrained stress and a significant decrease was observed in the number of leukocytes and lymphocytes than control, S+P and S+F (P<0. 05) whereas the number of neutrophils showed a significant increase then the others. Overall, our results indicate that Bioactive peptides derived from fermented Sardine could act as a potential functional ingredient with antioxidant activity for medicinal preparations.

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APA: Copy

HEYDARI, SH., hossein najdgerami, e., & NIKOO, M.. (2017). The effect of bioactive peptides mixture extracted from sardine on total antioxidant capacity of serum, lipid peroxidation and blood parameters in rats exposed to restraint stress. JOURNAL OF ANIMAL RESEARCH (IRANIAN JOURNAL OF BIOLOGY), 30(3 ), 0-0. SID. https://sid.ir/paper/397514/en

Vancouver: Copy

HEYDARI SH., hossein najdgerami e., NIKOO M.. The effect of bioactive peptides mixture extracted from sardine on total antioxidant capacity of serum, lipid peroxidation and blood parameters in rats exposed to restraint stress. JOURNAL OF ANIMAL RESEARCH (IRANIAN JOURNAL OF BIOLOGY)[Internet]. 2017;30(3 ):0-0. Available from: https://sid.ir/paper/397514/en

IEEE: Copy

SH. HEYDARI, e. hossein najdgerami, and M. NIKOO, “The effect of bioactive peptides mixture extracted from sardine on total antioxidant capacity of serum, lipid peroxidation and blood parameters in rats exposed to restraint stress,” JOURNAL OF ANIMAL RESEARCH (IRANIAN JOURNAL OF BIOLOGY), vol. 30, no. 3 , pp. 0–0, 2017, [Online]. Available: https://sid.ir/paper/397514/en

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