Analysis of Cell-Free DNA (as a genetic index for embryo quality) in an IranianWomen Undergoing IVF

Q: How can I download an article?

To download an article from SID, first log in to the site, search for the article title, and click on the 'Download Article' option.

Q: How can I download an ISI article?

To download an ISI article on SID, enter the keyword or article title in the search bar, view the relevant results, click on the desired article, and select the 'Download Article' option.

Q: How can I access the SID database?

To access the SID database, visit SID.ir, create an account, and log in to access scientific resources.

Q: Is downloading articles from SID free?

Some articles on SID are available for free, while others require payment. Details are specified on the article's page.

Ebrahim Shiva; Mehrabi Fatemeh; EBRAHIMI AHMAD

مرکز اطلاعات علمی Scientific Information Database (SID) - Trusted Source for Research and Academic Resources

Journal Paper

Paper Information

Journal: Journal of Epigenetics Year:2019 | Volume:1 | Issue:2 Page(s): 25-30

Download Full-Text

Persian Verion

View:

458

Download:

157

Cites:

Information Journal Paper

Title

Analysis of Cell-Free DNA (as a genetic index for embryo quality) in an IranianWomen Undergoing IVF

Author(s)

Ebrahim Shiva | Mehrabi Fatemeh | EBRAHIMI AHMAD | Issue Writer Certificate

Keywords

Cell-Free DNA

Follicular fluid

plasma

IVF

ALBUMIN

GAPDH

Abstract

Background: In vitro fertilization (IVF) is offered as a treatment for infertility in women. . The Cell free DNA in plasma/follicles were suggested as a biomarker for embryo quality in IVF. Higher the levels of Cell-Free DNA indicate poorer embryo quality in the Follicular fluid during IVF. Therefore, this study was designed to examine the Cell-Free DNA (cfDNA) in plasma and Fluid-follicle of women undergoing IVF-embryo transfer. 2) Methods: The study examined 100 women undergoing IVF treatment in an IVF unit in Yas Hospital of Tehran University of Medical Sciences in Tehran-Iran. Cell-Free DNA was extracted from plasma and Follicular fluid of patients using the NucleoSpin® Extraction Kit. The total cfDNA was examined by qPCR for ALBUMIN and GAPDH genes. 3) Results: we did not find a statistically significant association among the variables such as CT-plasma, CT-Follicular fluid, delta-CT and average of these data between two groups (including patients who had a successful IVF cycle and those who had a failed IVF cycle). 4) Conclusion: plasma and Follicular fluid cfDNA may reflect the presence of factors which interfere with embryo implantation. Further research is required to determine the usefulness of cfDNA as a biomarker of IVF outcome and to examine the underlying pathologies as potential sources for increased plasma/Follicular fluid cfDNA concentrations.

Cites

No record.

References

No record.

Cite

APA: Copy

Ebrahim, Shiva, Mehrabi, Fatemeh, & EBRAHIMI, AHMAD. (2019). Analysis of Cell-Free DNA (as a genetic index for embryo quality) in an IranianWomen Undergoing IVF. JOURNAL OF EPIGENETICS, 1(2 ), 25-30. SID. https://sid.ir/paper/400330/en

Vancouver: Copy

Ebrahim Shiva, Mehrabi Fatemeh, EBRAHIMI AHMAD. Analysis of Cell-Free DNA (as a genetic index for embryo quality) in an IranianWomen Undergoing IVF. JOURNAL OF EPIGENETICS[Internet]. 2019;1(2 ):25-30. Available from: https://sid.ir/paper/400330/en

IEEE: Copy

Shiva Ebrahim, Fatemeh Mehrabi, and AHMAD EBRAHIMI, “Analysis of Cell-Free DNA (as a genetic index for embryo quality) in an IranianWomen Undergoing IVF,” JOURNAL OF EPIGENETICS, vol. 1, no. 2 , pp. 25–30, 2019, [Online]. Available: https://sid.ir/paper/400330/en

Related Journal Papers