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Information Journal Paper

Title

Frequency of Prenatal Diagnosis of Chromosomal Abnormalities in Amniotic Fluid of Pregnant Women

Pages

  129-134

Abstract

 Aims Aminosynthesis is used as a powerful method to identify fetuses with chromosomal abnormalities. In this method, routine karyotyping and the gold standard method is used. The purpose of this study was to evaluate the frequency of Prenatal Diagnosis of chromosomal abnormalities in amniotic fluid during 2006-2017 in women referred to Sarem Women's Hospital. Materials & Methods In this experimental study, a total of 6298 amniotic fluid samples from pregnant women referred to Sarem Women's Hospital diagnosed high-risk were collected after Genetic Counseling from 2006 to 2017 and were chromosomally evaluated using standard cytogenetic and GTG bonding methods. Findings Frequency of referral indications included maternal serum screening 70. 8%, advanced maternal age 14. 3%, abnormal sonograghy 5. 1%, positive history of chromosomal diseases and rearrangements 3. 4%, maternal anxiety 1. 5% and other 5. 0%. The total rate of chromosome abnormality was 5. 1%. Chromosomal abnormalities rate for each group was: history of chromosomal rearrangements and diseases 11. 2%, abnormal sonograghy 9. 7%, advanced maternal age 5. 3%, abnormal maternal serum screening test 4. 4%, anxiety 2. 2%, and other referrals was 5. 7%. Conclusion Parents who are carriers for chromosomal rearrangements and women with foetal abnormal ultrasonic findings have great risks for chromosomal disorders in their fetuses. This study, as well as others, emphasizes the significance of karyotyping in pregnant woman with abnormal maternal serum screening test, advanced maternal age, history of chromosome abnormality, and abnormal sonograghy.

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    APA: Copy

    BEHJATI, F., Bagherizadeh, E., ABDI, A., Ghadami, E., MOUSAVI, F., SAEDI, E., MOHAMMADKHANI, N., Vand Rajabpour, F., & SHAFAGHATI, Y.. (2019). Frequency of Prenatal Diagnosis of Chromosomal Abnormalities in Amniotic Fluid of Pregnant Women. SAREM JOURNAL OF MEDICAL RESEARCH (SAREM JOURNAL OF REPRODUCTIVE MEDICINE), 4(3 ), 129-134. SID. https://sid.ir/paper/401494/en

    Vancouver: Copy

    BEHJATI F., Bagherizadeh E., ABDI A., Ghadami E., MOUSAVI F., SAEDI E., MOHAMMADKHANI N., Vand Rajabpour F., SHAFAGHATI Y.. Frequency of Prenatal Diagnosis of Chromosomal Abnormalities in Amniotic Fluid of Pregnant Women. SAREM JOURNAL OF MEDICAL RESEARCH (SAREM JOURNAL OF REPRODUCTIVE MEDICINE)[Internet]. 2019;4(3 ):129-134. Available from: https://sid.ir/paper/401494/en

    IEEE: Copy

    F. BEHJATI, E. Bagherizadeh, A. ABDI, E. Ghadami, F. MOUSAVI, E. SAEDI, N. MOHAMMADKHANI, F. Vand Rajabpour, and Y. SHAFAGHATI, “Frequency of Prenatal Diagnosis of Chromosomal Abnormalities in Amniotic Fluid of Pregnant Women,” SAREM JOURNAL OF MEDICAL RESEARCH (SAREM JOURNAL OF REPRODUCTIVE MEDICINE), vol. 4, no. 3 , pp. 129–134, 2019, [Online]. Available: https://sid.ir/paper/401494/en

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