Evaluation of RKIP gene expression changes of MDA-MB-231 breast cancer cell line after microgravity treatment

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SALAVATIFAR MARYAM; HAJEBRAHIMI ZAHRA

مرکز اطلاعات علمی Scientific Information Database (SID) - Trusted Source for Research and Academic Resources

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Paper Information

Journal: Journal of Space Science and Technology Year:2019 | Volume:12 | Issue:1 (38) Page(s): 69-76

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Title

Evaluation of RKIP gene expression changes of MDA-MB-231 breast cancer cell line after microgravity treatment

Author(s)

SALAVATIFAR MARYAM | HAJEBRAHIMI ZAHRA | Issue Writer Certificate

Keywords

RKIP proteinQ1

MDA-MB-231 cell lineQ1

microgravityQ1

metastasisQ1

clinostatQ1

Abstract

Gravity is one of the most important forces exposed to the organisms on the earth which affects the cells, molecules and thus the entire of organism. The purpose of this study is to investigate the effect of the simulated microgravity on the changes of RKIP metastasis suppressor gene expression on MDA-MB-231 breast cancer cell line. In order to impose microgravity state, cancer cells were placed on clinostat for one and three days. Then RNA was extracted from the cells and RKIP gene expression changes were evaluated by qReal time PCR. The findings showed that the microgravity during one day reduced the RKIP expression level, but with continuing up to three days, the expression returned to the control level. By optimizing the duration of microgravity, it can be likely observed the significant effects on the RKIP gene expression changes and so that useful steps can be taken to discover the cancer mechanisms and its treatment.

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APA: Copy

SALAVATIFAR, MARYAM, & HAJEBRAHIMI, ZAHRA. (2019). Evaluation of RKIP gene expression changes of MDA-MB-231 breast cancer cell line after microgravity treatment. JOURNAL OF SPACE SCIENCE AND TECHNOLOGY (JSST), 12(1 (38) ), 69-76. SID. https://sid.ir/paper/403567/en

Vancouver: Copy

SALAVATIFAR MARYAM, HAJEBRAHIMI ZAHRA. Evaluation of RKIP gene expression changes of MDA-MB-231 breast cancer cell line after microgravity treatment. JOURNAL OF SPACE SCIENCE AND TECHNOLOGY (JSST)[Internet]. 2019;12(1 (38) ):69-76. Available from: https://sid.ir/paper/403567/en

IEEE: Copy

MARYAM SALAVATIFAR, and ZAHRA HAJEBRAHIMI, “Evaluation of RKIP gene expression changes of MDA-MB-231 breast cancer cell line after microgravity treatment,” JOURNAL OF SPACE SCIENCE AND TECHNOLOGY (JSST), vol. 12, no. 1 (38) , pp. 69–76, 2019, [Online]. Available: https://sid.ir/paper/403567/en

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