Microgravity effect on expression of Raf kinase inhibitor protein on MCF-7 breast cancer cell line

Q: How can I download an article?

To download an article from SID, first log in to the site, search for the article title, and click on the 'Download Article' option.

Q: How can I download an ISI article?

To download an ISI article on SID, enter the keyword or article title in the search bar, view the relevant results, click on the desired article, and select the 'Download Article' option.

Q: How can I access the SID database?

To access the SID database, visit SID.ir, create an account, and log in to access scientific resources.

Q: Is downloading articles from SID free?

Some articles on SID are available for free, while others require payment. Details are specified on the article's page.

SALAVATIFAR MARYAM; HAJEBRAHIMI ZAHRA

Scientific Information Database (SID) - Trusted Source for Research and Academic Resources

Journal Paper

Paper Information

Journal: SCIENTIFIC JOURNAL OF KURDISTAN UNIVERSITY OF MEDICAL SCIENCES Year:2020 | Volume:24 | Issue:5 (103) Page(s): 42-55

Download Full-Text

مرکز اطلاعات علمی Scientific Information Database (SID) - Trusted Source for Research and Academic Resources

Persian Verion

View:

510

Download:

Cites:

Information Journal Paper

Title

Microgravity effect on expression of Raf kinase inhibitor protein on MCF-7 breast cancer cell line

Author(s)

SALAVATIFAR MARYAM | HAJEBRAHIMI ZAHRA | Issue Writer Certificate

Keywords

ClinostatQ1

GravityQ1

RKIP proteinQ1

TumorQ3

Abstract

Background and Aim: The living organisms on the earth are under the influence of natural Gravity force and if this gravitational force changes, they will be affected by a unique shock. Weightlessness has important effects on cell function by interfering with biochemical pathways and gene expressions. Study of these changes would be of benefit to astronauts and can improve the quality of human life on earth. In simulated microGravity, the expression of some genes and protein levels produced in cultured cells or laboratory animals have been altered. However, very little information is available on the effects of microGravity on gene expression. Raf kinase inhibitory protein (RKIP) is a regulator of kinase activity and a cell balancing agent that can act as a metastatic inhibitor in a variety of solid Tumors, including breast cancer. In general, the RKIP expression in progressive Tumors is reduced but its increased expression can result in reduced invasive potency of cancer cells without affecting primary Tumor growth. Materials and Methods: In this study, changes of RKIP gene expression were investigated in human MCF-7 breast cancer cells after 24 and 72 hours exposure to microGravity conditions using qReal time PCR method. We used t-test for data analysis and graphpad prism 7 project for plotting graphs. Results: The results showed that microGravity changed gene expression of RKIP and led to increased expression levels of the gene after 24 hours exposure to microGravity. Conclusions: By optimizing the duration of microGravity, we can observe significant changes in RKIP gene expression in MCF-7 cell line which can be considered promising for the treatment of cancer.

Cites

No record.

References

No record.

Cite

APA: Copy

SALAVATIFAR, MARYAM, & HAJEBRAHIMI, ZAHRA. (2020). Microgravity effect on expression of Raf kinase inhibitor protein on MCF-7 breast cancer cell line. SCIENTIFIC JOURNAL OF KURDISTAN UNIVERSITY OF MEDICAL SCIENCES, 24(5 (103) ), 42-55. SID. https://sid.ir/paper/76432/en

Vancouver: Copy

SALAVATIFAR MARYAM, HAJEBRAHIMI ZAHRA. Microgravity effect on expression of Raf kinase inhibitor protein on MCF-7 breast cancer cell line. SCIENTIFIC JOURNAL OF KURDISTAN UNIVERSITY OF MEDICAL SCIENCES[Internet]. 2020;24(5 (103) ):42-55. Available from: https://sid.ir/paper/76432/en

IEEE: Copy

MARYAM SALAVATIFAR, and ZAHRA HAJEBRAHIMI, “Microgravity effect on expression of Raf kinase inhibitor protein on MCF-7 breast cancer cell line,” SCIENTIFIC JOURNAL OF KURDISTAN UNIVERSITY OF MEDICAL SCIENCES, vol. 24, no. 5 (103) , pp. 42–55, 2020, [Online]. Available: https://sid.ir/paper/76432/en

Related Journal Papers