Rare Cytogenetic Findings of Two Iranian Female Patients with Premature Ovarian Failure

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ABDI A.; BAGHERIZADEH I.; Vand Rajabpour F.; SHAFAGHATI Y.; BEHJATI F.

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Paper Information

Journal: SAREM JOURNAL OF MEDICAL RESEARCH (SAREM JOURNAL OF REPRODUCTIVE MEDICINE) Year:2019 | Volume:4 | Issue:2 Page(s): 123-126

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Title

Rare Cytogenetic Findings of Two Iranian Female Patients with Premature Ovarian Failure

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Keywords

Premature ovarian failure (POF)

Chromosomal abnormality

X chromosome

Abstract

Introduction Premature ovarian failure (POF) is defined by ovarian failure, amenorrhea, sex steroid deficiency, and elevated (menopausal) levels of serum gonadotropins before the age of 40 years. Chromosome abnormalities are the cause of 5-10% of POF cases. The aim of this study was to report chromosomal abnormalities, with X chromosome involvement, in two patients with POF, referred to Sarem Hospital in Tehran. Patients’ Information Two patients with a POF diagnosis were referred to the cytogenetic laboratory of Sarem Hospital in 2014-20115. The chromosomal analysis of a 16-year-old girl and a 26-year-old woman (both with POF) by high resolution GTG banding technique showed structural chromosome abnormities and 46, X, der(X) and 45, dic(X; 22)(q22; p12) Karyotypes were observed, respectively. Conclusion Cytogenetic investigation in patients with POF is of great value and highly recommended.

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APA: Copy

ABDI, A., BAGHERIZADEH, I., Vand Rajabpour, F., SHAFAGHATI, Y., & BEHJATI, F.. (2019). Rare Cytogenetic Findings of Two Iranian Female Patients with Premature Ovarian Failure. SAREM JOURNAL OF MEDICAL RESEARCH (SAREM JOURNAL OF REPRODUCTIVE MEDICINE), 4(2 ), 123-126. SID. https://sid.ir/paper/404138/en

Vancouver: Copy

ABDI A., BAGHERIZADEH I., Vand Rajabpour F., SHAFAGHATI Y., BEHJATI F.. Rare Cytogenetic Findings of Two Iranian Female Patients with Premature Ovarian Failure. SAREM JOURNAL OF MEDICAL RESEARCH (SAREM JOURNAL OF REPRODUCTIVE MEDICINE)[Internet]. 2019;4(2 ):123-126. Available from: https://sid.ir/paper/404138/en

IEEE: Copy

A. ABDI, I. BAGHERIZADEH, F. Vand Rajabpour, Y. SHAFAGHATI, and F. BEHJATI, “Rare Cytogenetic Findings of Two Iranian Female Patients with Premature Ovarian Failure,” SAREM JOURNAL OF MEDICAL RESEARCH (SAREM JOURNAL OF REPRODUCTIVE MEDICINE), vol. 4, no. 2 , pp. 123–126, 2019, [Online]. Available: https://sid.ir/paper/404138/en

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