Evaluation of methylcellulose role in thermosensitive hydrogel structure as injectable system for tissue engineering application: fabrication and characterization

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Motalebi Tala Tapeh Sogol; Sharifzadeh Baei Mazyar; Heydari Keshel Saeed

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Journal: Journal of Applied Research in Chemistry Year:2020 | Volume:14 | Issue:2 Page(s): 27-46

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Information Journal Paper

Title

Evaluation of methylcellulose role in thermosensitive hydrogel structure as injectable system for tissue engineering application: fabrication and characterization

Author(s)

Motalebi Tala Tapeh Sogol | Sharifzadeh Baei Mazyar | Heydari Keshel Saeed | Issue Writer Certificate

Keywords

Soft tissues engineeringQ1

Thermosensitive hydrogelQ1

MethylcelluloseQ1

BiocompatibilityQ1

Abstract

One of the challenges in tissue engineering is polymer material selection and design of a suitable structure for hydrogels. In this study, N-isopropylacrylamide/Acrylic acid/N-Acryloxysuccinicimide/2Hydroxyethyl methacrylate-poly lactide hydrogel )NIPAAm/AAC/NAS/HEMAPLA( was prepared with various molar ratio by ring-opening polymerization method to fabricate hydrogel substrate with properties of injectability, thermosensitive, physical and mechanical similar of soft tissues. The hydrogel with the ratio of 80/5/5/10 was selected as ideal groups )group 1(. Methylcellulose was also used in the hydrogel structure to improve quality of the hydrogel )group 4(. Then, the physicochemical, mechanical and biological properties of the hydrogels were evaluated. The results showed, molar ratio of polymers not only plays an important role in enhancing hydrophilicity, porosity, elastic modulus-like soft tissues, and cell proliferation, but also the presence of methyl cellulose lead to the improvement of the mentioned properties. So that, hydrogels of groups 1 and 4 provide an ideal environment for improving cellular activities due to hydrophilicity of more than 51%, elastic modulus-like cardiac tissues )68. 1 kPa and 79. 22 kPa, respectively(, Biocompatibility above 90%, with compared to other groups. It seems that the mentioned hydrogels )1 and 4 groups( can imitate soft tissue properties such as cardiac and be effective to regenerate and repair. In the other hand, these thermosensitive and inject ability hydrogels lead to a uniform mixing of cells and growth factors, as well as can apply to the cell therapy of soft tissue.

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APA: Copy

Motalebi Tala Tapeh, Sogol, Sharifzadeh Baei, Mazyar, & Heydari Keshel, Saeed. (2020). Evaluation of methylcellulose role in thermosensitive hydrogel structure as injectable system for tissue engineering application: fabrication and characterization. JOURNAL OF APPLIED RESEARCHES IN CHEMISTRY (JARC), 14(2 ), 27-46. SID. https://sid.ir/paper/410756/en

Vancouver: Copy

Motalebi Tala Tapeh Sogol, Sharifzadeh Baei Mazyar, Heydari Keshel Saeed. Evaluation of methylcellulose role in thermosensitive hydrogel structure as injectable system for tissue engineering application: fabrication and characterization. JOURNAL OF APPLIED RESEARCHES IN CHEMISTRY (JARC)[Internet]. 2020;14(2 ):27-46. Available from: https://sid.ir/paper/410756/en

IEEE: Copy

Sogol Motalebi Tala Tapeh, Mazyar Sharifzadeh Baei, and Saeed Heydari Keshel, “Evaluation of methylcellulose role in thermosensitive hydrogel structure as injectable system for tissue engineering application: fabrication and characterization,” JOURNAL OF APPLIED RESEARCHES IN CHEMISTRY (JARC), vol. 14, no. 2 , pp. 27–46, 2020, [Online]. Available: https://sid.ir/paper/410756/en

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