The Protective Effects of Hydroalcoholic Extract of Passiflora caerulea Aerial Parts Against Hepatic Dysfunction Induced by Cadmium Chloride in Adult Male Rats

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GHAVAMI M.; SHARIATI M.; MOKHTARI M.; KHATAMSAZ S.

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Paper Information

Journal: JOURNAL OF ANIMAL PHYSIOLOGY AND DEVELOPMENT (QUARTERLY JOURNAL OF BIOLOGICAL SCIENCES) Year:2020 | Volume:13 | Issue:4 (51) Page(s): 25-37

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Title

The Protective Effects of Hydroalcoholic Extract of Passiflora caerulea Aerial Parts Against Hepatic Dysfunction Induced by Cadmium Chloride in Adult Male Rats

Author(s)

GHAVAMI M. | SHARIATI M. | MOKHTARI M. | KHATAMSAZ S. | Issue Writer Certificate

Keywords

Passiflora caeruleaQ1

Cadmium ChlorideQ1

Hepatic DysfunctionQ1

Adult Male RatsQ1

Abstract

Inroduction & Objective: Cadmium Chloride causes liver injury. In this study, the protective effect of hydroalcoholic extract of Passifloracaerulea aerial parts against Hepatic Dysfunction induced by Cadmium Chloride in Adult Male Rats was investigated. Material and Methods: Fifty-four Adult Male Rats were divided into 6 groups of 9: control group; sham group1: received 0. 2ml/kg distilled water daily intraperitoneally as solvent. Sham group2; received 2 mg/kg Cadmium Chloride daily intraperitoneally during 21 days; experimental groups 1, 2 and 3: received 2 mg/kg Cadmium Chloride daily intraperitoneally during 21 days and then the hydroalcoholic extract of Passifloracaerulea aerial parts at the doses of 150, 300, 450mg/kg intraperitoneally during 30 days. The serum levels of AST, ALT, ALP, GGT, LDH, albumin, bilirubin, and total protein were measured. The pathological examination of hepatic tissue samples were done after hematoxylin-eosin staining Results: The mean levels of ALT, ALP, GGT, LDH and bilirubin in the all experimental groups showed a significant decrease compared to the group receiving Cadmium Chloride. The mean levels of AST in the experimental groups 2 and 3 showed a significant decrease compared to the group receiving Cadmium Chloride. The mean serum albumin and total protein concentration in experimental groups 2and 3 increased significantly compared to the group receiving Cadmium Chloride. In all experimental groups the hepatic tissue changes induced by Cadmium Chloride improved which were dose dependent (P˂ 0. 05). Conclusion: The results of this study showed that the hydroalcoholic extract of Passifloracaerulea aerial parts had protective effects against the Hepatic Dysfunction induced by Cadmium Chloride in Adult Male Rats.

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APA: Copy

GHAVAMI, M., SHARIATI, M., MOKHTARI, M., & KHATAMSAZ, S.. (2020). The Protective Effects of Hydroalcoholic Extract of Passiflora caerulea Aerial Parts Against Hepatic Dysfunction Induced by Cadmium Chloride in Adult Male Rats. JOURNAL OF ANIMAL PHYSIOLOGY AND DEVELOPMENT (QUARTERLY JOURNAL OF BIOLOGICAL SCIENCES), 13(4 (51) ), 25-37. SID. https://sid.ir/paper/410848/en

Vancouver: Copy

GHAVAMI M., SHARIATI M., MOKHTARI M., KHATAMSAZ S.. The Protective Effects of Hydroalcoholic Extract of Passiflora caerulea Aerial Parts Against Hepatic Dysfunction Induced by Cadmium Chloride in Adult Male Rats. JOURNAL OF ANIMAL PHYSIOLOGY AND DEVELOPMENT (QUARTERLY JOURNAL OF BIOLOGICAL SCIENCES)[Internet]. 2020;13(4 (51) ):25-37. Available from: https://sid.ir/paper/410848/en

IEEE: Copy

M. GHAVAMI, M. SHARIATI, M. MOKHTARI, and S. KHATAMSAZ, “The Protective Effects of Hydroalcoholic Extract of Passiflora caerulea Aerial Parts Against Hepatic Dysfunction Induced by Cadmium Chloride in Adult Male Rats,” JOURNAL OF ANIMAL PHYSIOLOGY AND DEVELOPMENT (QUARTERLY JOURNAL OF BIOLOGICAL SCIENCES), vol. 13, no. 4 (51) , pp. 25–37, 2020, [Online]. Available: https://sid.ir/paper/410848/en

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