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Information Journal Paper

Title

Synthesis of phenylcarbamate derivatives using amino acids and study of their effects on the morphology of pheochromocytoma cells (PC12)

Pages

  108-123

Abstract

 In this study, new derivatives of (2-chloro-5-(trifluoromethyl)phenyl)carbamic acid phenyl ester, were synthesized using Cysteine, Tryptophan, Aspartic acid, and Isoleucine amino acids as well as their methyl esters. These compounds were selected from the four main classes of amino acids: (polar without charg), (nonpolar and aromatic), (polar with negative charge), and (nonpolar and aliphatic), respectively. The molecular structures of all products were identified and confirmed using HNMR and FT-IR spectroscopic methods. Finally, pure compounds ((2-chloro-5-(triflouromethyl)phenyl)carbamoyle)-D-Tryptophan and 1-(2-chloro-5-(triflouromethyl)phenyl)-2, 6-dioxohexahydropyrimidine-4-carboxylic acid, were tested for their effects on the pheochromocytoma cells’ morphology using microscopic imaging. The calculated lethal dose was 10  M and the assay time was 48 h. Visual inspection of invert microscope images revealed acceptable lethal effect of synthetic products.

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    APA: Copy

    NIKPOUR NEZHATI, MAHSHID, Riazi, Gholamhossein, Golestanefar, Safiye Sadat, Hoseini Rostami, Fatemeh Sadat, Mohamad Hosseini, Hamid, & Golestani, Samane. (2021). Synthesis of phenylcarbamate derivatives using amino acids and study of their effects on the morphology of pheochromocytoma cells (PC12). JOURNAL OF APPLIED RESEARCHES IN CHEMISTRY (JARC), 14(4 ), 108-123. SID. https://sid.ir/paper/410902/en

    Vancouver: Copy

    NIKPOUR NEZHATI MAHSHID, Riazi Gholamhossein, Golestanefar Safiye Sadat, Hoseini Rostami Fatemeh Sadat, Mohamad Hosseini Hamid, Golestani Samane. Synthesis of phenylcarbamate derivatives using amino acids and study of their effects on the morphology of pheochromocytoma cells (PC12). JOURNAL OF APPLIED RESEARCHES IN CHEMISTRY (JARC)[Internet]. 2021;14(4 ):108-123. Available from: https://sid.ir/paper/410902/en

    IEEE: Copy

    MAHSHID NIKPOUR NEZHATI, Gholamhossein Riazi, Safiye Sadat Golestanefar, Fatemeh Sadat Hoseini Rostami, Hamid Mohamad Hosseini, and Samane Golestani, “Synthesis of phenylcarbamate derivatives using amino acids and study of their effects on the morphology of pheochromocytoma cells (PC12),” JOURNAL OF APPLIED RESEARCHES IN CHEMISTRY (JARC), vol. 14, no. 4 , pp. 108–123, 2021, [Online]. Available: https://sid.ir/paper/410902/en

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