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Information Journal Paper

Title

Synthesis of new coumarin derivatives by using Ti– Al/Al2o3 nanocomposite and evaluation of their antibacterial activity

Pages

  127-136

Keywords

Pyrano [2Q1

Abstract

 Due to the importance of coumarin derivatives and specially pyrano coumarins, as well as their different chemical and biological properties, we synthesized pyrano [2, 3-h] coumarins by using reactions of 5, 7-dihydroxy-4-methylcoumarin, aryl aldehydes, and malononitrile in the presence of Ti– Al/Al2 O3 nanocomposite in methanol. The structures of the products were identified by FIIR, 1 H-NMR, and 13 C-NMR spectroscopy. The excellent yields, simplicity, easy work-up and short reaction times are the most significant advantages of this method. Some antibacterial activities were evaluated via the disk diffusion method and the results showed that 8-amino-5-hydroxy-4-methyl-2-oxo-10-phenyl-2, 10-dihydropyrano[2, 3-f] chromene-9-carbonitrile (7) has significant pharmaceutical activities as antibacterial reagent comparing to Staphylococcus aureus and Escherichia coli.

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  • Cite

    APA: Copy

    Bahramnezhad, Baharak, GHAZANFARI, DADKHODA, SHEIKHHOSSEINI, ENAYATOLLAH, AKHGAR, MOHAMMAD REZA, & AHMADI, SEYED ALI. (2020). Synthesis of new coumarin derivatives by using Ti– Al/Al2o3 nanocomposite and evaluation of their antibacterial activity. JOURNAL OF APPLIED RESEARCHES IN CHEMISTRY (JARC), 14(1 ), 127-136. SID. https://sid.ir/paper/410910/en

    Vancouver: Copy

    Bahramnezhad Baharak, GHAZANFARI DADKHODA, SHEIKHHOSSEINI ENAYATOLLAH, AKHGAR MOHAMMAD REZA, AHMADI SEYED ALI. Synthesis of new coumarin derivatives by using Ti– Al/Al2o3 nanocomposite and evaluation of their antibacterial activity. JOURNAL OF APPLIED RESEARCHES IN CHEMISTRY (JARC)[Internet]. 2020;14(1 ):127-136. Available from: https://sid.ir/paper/410910/en

    IEEE: Copy

    Baharak Bahramnezhad, DADKHODA GHAZANFARI, ENAYATOLLAH SHEIKHHOSSEINI, MOHAMMAD REZA AKHGAR, and SEYED ALI AHMADI, “Synthesis of new coumarin derivatives by using Ti– Al/Al2o3 nanocomposite and evaluation of their antibacterial activity,” JOURNAL OF APPLIED RESEARCHES IN CHEMISTRY (JARC), vol. 14, no. 1 , pp. 127–136, 2020, [Online]. Available: https://sid.ir/paper/410910/en

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