Preparation and identification of 4-benzenesulfonamidethiophenol grafted on silver nanoparticles and binding studies with calf thymus DNA, human serum albumin and bovin serum albumin using spectroscopic and molecular docking methods

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AMIRI FERESHTEH; SADEGHI MARZIEH; SHOKRI TAHEREH

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Journal: Journal of Applied Research in Chemistry Year:2021 | Volume:14 | Issue:4 Page(s): 51-73

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Title

Preparation and identification of 4-benzenesulfonamidethiophenol grafted on silver nanoparticles and binding studies with calf thymus DNA, human serum albumin and bovin serum albumin using spectroscopic and molecular docking methods

Author(s)

AMIRI FERESHTEH | SADEGHI MARZIEH | SHOKRI TAHEREH | Issue Writer Certificate

Keywords

BSATP functionalized silver nanparticlesQ1

DNAQ2

Human serum albuminQ1

Bovine serum albuminQ2

Spectrocopic studiesQ1

Molecular duckingQ1

Abstract

In this article, silver nanoparticles capped with 4- benzenesulfonamideaminothiophenol (BSATP-AgNP) were synthesized. The formation of synthesized nanoparticles was characterized by UV– Vis spectroscopy, FTIR, TEM, and NMR. The interactions between the silver nanoparticles with calf-thymus DNA, Human serum albumin (HAS) and Bovine serum albumin (BSA) were investigated by UV-Vis spectroscopy, fluorescence spectroscopy, circular dicroism (CD) spectroscopy, viscosity measurements, and molecular docking studies. Circular dicroism data showed that binding of BSATP-AgNPs to DNA resulted in changes in the structure and conformation of DNA. This indicates a minor groove mode of binding. Fluorimeteric studies showed a decrease in fluorescence intensity of the BSATP-AgNPs in the presence of increasing amounts of DNA solution. The results of CD data indicate that the conformation of HSA and BSA molecules is changed signiﬁ cantly in the presence of BSATP-AgNPs. The negative Δ H and Δ S values indicate that the main interactions between BSATP-AgNPs and HSA were hydrogen bonding and weak van der Waals forces. The results of the site marker competitive experiment confirmed that the BSATP AgNPs can bind to HSA located within site I (subdomain IIA) and BSA within site II. The experimental results were in agreement with the results obtained via a molecular docking study. This study provided important insight into the interaction of BSATPAgNPs with DNA and serum albumin, facilitating further investigation on the pharmacological behavior of BSATP-AgNPs.

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APA: Copy

AMIRI, FERESHTEH, SADEGHI, MARZIEH, & SHOKRI, TAHEREH. (2021). Preparation and identification of 4-benzenesulfonamidethiophenol grafted on silver nanoparticles and binding studies with calf thymus DNA, human serum albumin and bovin serum albumin using spectroscopic and molecular docking methods. JOURNAL OF APPLIED RESEARCHES IN CHEMISTRY (JARC), 14(4 ), 51-73. SID. https://sid.ir/paper/411038/en

Vancouver: Copy

AMIRI FERESHTEH, SADEGHI MARZIEH, SHOKRI TAHEREH. Preparation and identification of 4-benzenesulfonamidethiophenol grafted on silver nanoparticles and binding studies with calf thymus DNA, human serum albumin and bovin serum albumin using spectroscopic and molecular docking methods. JOURNAL OF APPLIED RESEARCHES IN CHEMISTRY (JARC)[Internet]. 2021;14(4 ):51-73. Available from: https://sid.ir/paper/411038/en

IEEE: Copy

FERESHTEH AMIRI, MARZIEH SADEGHI, and TAHEREH SHOKRI, “Preparation and identification of 4-benzenesulfonamidethiophenol grafted on silver nanoparticles and binding studies with calf thymus DNA, human serum albumin and bovin serum albumin using spectroscopic and molecular docking methods,” JOURNAL OF APPLIED RESEARCHES IN CHEMISTRY (JARC), vol. 14, no. 4 , pp. 51–73, 2021, [Online]. Available: https://sid.ir/paper/411038/en

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