Design of hybrid porous scaffold based on PEPC composite modified with chitosan to apply in soft tissue engineering: Evaluation of structural similarities and mechanobiological behavior

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Izadyari Aghmiuni Azadeh; Sharifzadeh Baei Mazyar; HEIDARI KESHEL SAEED; AKBARZADEH KHIYAVI AZIM

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Journal: Journal of Applied Research in Chemistry Year:2020 | Volume:14 | Issue:1 Page(s): 91-108

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Information Journal Paper

Title

Design of hybrid porous scaffold based on PEPC composite modified with chitosan to apply in soft tissue engineering: Evaluation of structural similarities and mechanobiological behavior

Author(s)

Izadyari Aghmiuni Azadeh | Sharifzadeh Baei Mazyar | HEIDARI KESHEL SAEED | AKBARZADEH KHIYAVI AZIM | Issue Writer Certificate

Keywords

Soft tissue engineeringQ1

Natural polymersQ1

Hybrid scaffoldsQ1

Micro-porous mediaQ1

Abstract

Nowadays, tissue engineering is known as one of the effective treatments to repair soft and hard tissues; although, the design of the substrates that mimic the cell growth pattern and mechanobiological function of tissue is a great challenge. In the present study, to evaluate the role of natural and synthetic polymers combination in mimicking biological environment, the porous scaffolds of PEPC )PEG/PCL(, and PCP )PEG/Chitosan/PCL( were designed by the freeze-dried method. Then, the physicochemical, mechanical and biological properties of the mentioned scaffolds were evaluated and compared with those of designed scaffolds )Chitosan, PEG, PCL(. The results showed that the combination of polymers )natural/synthetic( plays a major role in the formation of Micro-porous media and extracellular matrix-like elasticity. So that, the PCP hybrid scaffold provided a higher porosity )with lower pores diameter( and elastic modulus of soft tissue-like )5. 11 MPa(, compared to PEPC composite scaffold. Moreover, the presence of chitosan in PCP scaffold led to an increase in the swelling, the control of degradation rate, and improvement of cell proliferation (96%) as compared to other groups. Therefore, it seems that PCP hybrid scaffold can play an important role in tissue regeneration via mimicking morphology and mechanobiological behaviors of soft tissues such as skin, ligament, endothelium, and blood vessels.

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APA: Copy

Izadyari Aghmiuni, Azadeh, Sharifzadeh Baei, Mazyar, HEIDARI KESHEL, SAEED, & AKBARZADEH KHIYAVI, AZIM. (2020). Design of hybrid porous scaffold based on PEPC composite modified with chitosan to apply in soft tissue engineering: Evaluation of structural similarities and mechanobiological behavior. JOURNAL OF APPLIED RESEARCHES IN CHEMISTRY (JARC), 14(1 ), 91-108. SID. https://sid.ir/paper/411472/en

Vancouver: Copy

Izadyari Aghmiuni Azadeh, Sharifzadeh Baei Mazyar, HEIDARI KESHEL SAEED, AKBARZADEH KHIYAVI AZIM. Design of hybrid porous scaffold based on PEPC composite modified with chitosan to apply in soft tissue engineering: Evaluation of structural similarities and mechanobiological behavior. JOURNAL OF APPLIED RESEARCHES IN CHEMISTRY (JARC)[Internet]. 2020;14(1 ):91-108. Available from: https://sid.ir/paper/411472/en

IEEE: Copy

Azadeh Izadyari Aghmiuni, Mazyar Sharifzadeh Baei, SAEED HEIDARI KESHEL, and AZIM AKBARZADEH KHIYAVI, “Design of hybrid porous scaffold based on PEPC composite modified with chitosan to apply in soft tissue engineering: Evaluation of structural similarities and mechanobiological behavior,” JOURNAL OF APPLIED RESEARCHES IN CHEMISTRY (JARC), vol. 14, no. 1 , pp. 91–108, 2020, [Online]. Available: https://sid.ir/paper/411472/en

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