PURIFICATION AND CHARACTERIZATION OF AN ANTIBACTERIAL, ANTIFUNGAL AND NON HEMOLYTIC PEPTIDE FROM RANA RIDIBUNDA

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ASOODEH A.; NADERIMANESH H.; MIRSHAHI M.; RANJBAR B.

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Journal Paper

Paper Information

Journal: Journal of Sciences, Islamic Republic of Iran Year:2004 | Volume:15 | Issue:4 Page(s): 303-309

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Title

PURIFICATION AND CHARACTERIZATION OF AN ANTIBACTERIAL, ANTIFUNGAL AND NON HEMOLYTIC PEPTIDE FROM RANA RIDIBUNDA

Author(s)

ASOODEH A. | NADERIMANESH H. | MIRSHAHI M. | RANJBAR B. | Issue Writer Certificate

Keywords

ANTIBACTERIAL PEPTIDE; HEMOLYSIS; RANA RIDIBUNDA

Abstract

Amphibians have a large variety of antimicrobial peptides that serve as natural innate barriers limiting microbial infection or, in some instances, act as an integral component in response to inflammation or microbial infection. A novel peptide with antibacterial effects and without hemolytic activity was purified from skin secretions of Rana ridibunda by multisteps cation-exchange FPLC, reversedphase HPLC and was called Ridibundin 1. Circular dichroism spectra revealed that this peptide strongly prefers to form an amphipathic ل-helical structure in the presence of 50% trifluoroethanol. Acting as wide-spectrum microbicides against a variety of bacteria, Ridibundin 1 also shows no hemolytic activity on erythrocyte. These properties reveal its unique characteristics and potential therapeutic application.

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APA: Copy

ASOODEH, A., NADERIMANESH, H., MIRSHAHI, M., & RANJBAR, B.. (2004). PURIFICATION AND CHARACTERIZATION OF AN ANTIBACTERIAL, ANTIFUNGAL AND NON HEMOLYTIC PEPTIDE FROM RANA RIDIBUNDA. JOURNAL OF SCIENCES ISLAMIC REPUBLIC OF IRAN, 15(4), 303-309. SID. https://sid.ir/paper/529621/en

Vancouver: Copy

ASOODEH A., NADERIMANESH H., MIRSHAHI M., RANJBAR B.. PURIFICATION AND CHARACTERIZATION OF AN ANTIBACTERIAL, ANTIFUNGAL AND NON HEMOLYTIC PEPTIDE FROM RANA RIDIBUNDA. JOURNAL OF SCIENCES ISLAMIC REPUBLIC OF IRAN[Internet]. 2004;15(4):303-309. Available from: https://sid.ir/paper/529621/en

IEEE: Copy

A. ASOODEH, H. NADERIMANESH, M. MIRSHAHI, and B. RANJBAR, “PURIFICATION AND CHARACTERIZATION OF AN ANTIBACTERIAL, ANTIFUNGAL AND NON HEMOLYTIC PEPTIDE FROM RANA RIDIBUNDA,” JOURNAL OF SCIENCES ISLAMIC REPUBLIC OF IRAN, vol. 15, no. 4, pp. 303–309, 2004, [Online]. Available: https://sid.ir/paper/529621/en

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