DETECTION OF ABL/BCR FUSION GENE IN PATIENTS AFFECTED BY CHRONIC MYELOID LEUKAEMIA BY DUAL-COLOUR INTERPHASE FLUORESCENCE IN SITU HYBRIDISATION

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MOHADDES S.M.; TABATABAEI S.M.; JAVADI G.H.; NIKANFAR A.R.

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Journal Paper

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Journal: Journal of Sciences, Islamic Republic of Iran Year:2004 | Volume:15 | Issue:4 Page(s): 321-325

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Title

DETECTION OF ABL/BCR FUSION GENE IN PATIENTS AFFECTED BY CHRONIC MYELOID LEUKAEMIA BY DUAL-COLOUR INTERPHASE FLUORESCENCE IN SITU HYBRIDISATION

Author(s)

MOHADDES S.M. | TABATABAEI S.M. | JAVADI G.H. | NIKANFAR A.R. | Issue Writer Certificate

Keywords

CML; INTERPHASE FISH; ABL/BCR FUSION; PHILADELPHIA CHROMOSOME

Abstract

Conventional cytogenetic is the standard technique for detection of Philadelphia (Ph) chromosome in chronic myeloid leukemia (CML). Evaluation of abelson murine leukemia/breakpoint cluster region (abl/bcr) fusion using dualcolour fluorescence in situ hybridization (D-FISH) is an alternative approach allowing rapid and reliable detection of the disease. We employed the technique of interphase D-FISH to detect the abl/bcr fusion in 21 patients and the results were compared to those of conventional cytogenetic analysis. A significant agreement was observed between the results, indicating the accuracy of interphase D-FISH. The technique can overcome the disadvantage of conventional cytogenetic methods, which depends on cell culture and analysis of banded chromosomes, since the analysis is performed by signal counting on uncultured target cells. Furthermore D-FISH provides a more reliable method for evaluating the degree of clone remission to patients with CML after therapy compared to the conventional cytogenetic analysis.

Cites

RELIABILITY EVALUATION OF FLUORESCENCE IN SITU HYBRIDIZATION (FISH) AND G-BANDING ON BONE MARROW AND PERIPHERAL BLOOD CELLS IN CHRONIC MYELOGENOUS LEUKEMIA PATIENTS

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APA: Copy

MOHADDES, S.M., TABATABAEI, S.M., JAVADI, G.H., & NIKANFAR, A.R.. (2004). DETECTION OF ABL/BCR FUSION GENE IN PATIENTS AFFECTED BY CHRONIC MYELOID LEUKAEMIA BY DUAL-COLOUR INTERPHASE FLUORESCENCE IN SITU HYBRIDISATION. JOURNAL OF SCIENCES ISLAMIC REPUBLIC OF IRAN, 15(4), 321-325. SID. https://sid.ir/paper/529800/en

Vancouver: Copy

MOHADDES S.M., TABATABAEI S.M., JAVADI G.H., NIKANFAR A.R.. DETECTION OF ABL/BCR FUSION GENE IN PATIENTS AFFECTED BY CHRONIC MYELOID LEUKAEMIA BY DUAL-COLOUR INTERPHASE FLUORESCENCE IN SITU HYBRIDISATION. JOURNAL OF SCIENCES ISLAMIC REPUBLIC OF IRAN[Internet]. 2004;15(4):321-325. Available from: https://sid.ir/paper/529800/en

IEEE: Copy

S.M. MOHADDES, S.M. TABATABAEI, G.H. JAVADI, and A.R. NIKANFAR, “DETECTION OF ABL/BCR FUSION GENE IN PATIENTS AFFECTED BY CHRONIC MYELOID LEUKAEMIA BY DUAL-COLOUR INTERPHASE FLUORESCENCE IN SITU HYBRIDISATION,” JOURNAL OF SCIENCES ISLAMIC REPUBLIC OF IRAN, vol. 15, no. 4, pp. 321–325, 2004, [Online]. Available: https://sid.ir/paper/529800/en

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