EXPRESSION OF INDUCIBLE NITRIC OXIDE SYNTHASE GENE (INOS) STIMULATED BY HYDROGEN PEROXIDE IN HUMAN ENDOTHELIAL CELLS

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EBRAHIMI M.; SADEGHIZADEH M.; NOURI DALOUEI M.R.

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Journal Paper

Paper Information

Journal: Journal of Sciences, Islamic Republic of Iran Year:2002 | Volume:13 | Issue:1 Page(s): 15-18

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Information Journal Paper

Title

EXPRESSION OF INDUCIBLE NITRIC OXIDE SYNTHASE GENE (INOS) STIMULATED BY HYDROGEN PEROXIDE IN HUMAN ENDOTHELIAL CELLS

Author(s)

EBRAHIMI M. | SADEGHIZADEH M. | NOURI DALOUEI M.R. | Issue Writer Certificate

Keywords

NITRIC OXIDE; INDUCIBLE NITRIC OXIDE SYNTHASE; MRNA EXPRESSION; HUMAN ENDOTHELIAL CELLS

Abstract

Inducible nitric oxide synthase (iNOS) gene expresses a calcium calmudolinindependent enzyme which can catalyse NO production from L-arginine. The induction of iNOS activity has been demonstrated in a wide variety of cell types under stimulation with cytokines and lipopoly saccharide (LPS). Previous studies indicated that all nitric oxide synthases (NOS) activated in human umbilical vein endothelial cells (HUVEC) were calcium dependent. In this work we indicate that endothelial cells can express iNOS mRNA under stimulation by cytokines, LPS and H2O2. We also found that iNOS mRNA expression has increased by augmentation of H2O2 concentration and its expression depends on increasing in time. Therefore we conclude that two isoforms of NOS are expressed in the HUVEC and induction of iNOS enzyme by H2O2 and NO production in endothelial cells may represent a novel cellular defence mechanism against oxidative stress and infections.

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APA: Copy

EBRAHIMI, M., SADEGHIZADEH, M., & NOURI DALOUEI, M.R.. (2002). EXPRESSION OF INDUCIBLE NITRIC OXIDE SYNTHASE GENE (INOS) STIMULATED BY HYDROGEN PEROXIDE IN HUMAN ENDOTHELIAL CELLS. JOURNAL OF SCIENCES ISLAMIC REPUBLIC OF IRAN, 13(1), 15-18. SID. https://sid.ir/paper/532071/en

Vancouver: Copy

EBRAHIMI M., SADEGHIZADEH M., NOURI DALOUEI M.R.. EXPRESSION OF INDUCIBLE NITRIC OXIDE SYNTHASE GENE (INOS) STIMULATED BY HYDROGEN PEROXIDE IN HUMAN ENDOTHELIAL CELLS. JOURNAL OF SCIENCES ISLAMIC REPUBLIC OF IRAN[Internet]. 2002;13(1):15-18. Available from: https://sid.ir/paper/532071/en

IEEE: Copy

M. EBRAHIMI, M. SADEGHIZADEH, and M.R. NOURI DALOUEI, “EXPRESSION OF INDUCIBLE NITRIC OXIDE SYNTHASE GENE (INOS) STIMULATED BY HYDROGEN PEROXIDE IN HUMAN ENDOTHELIAL CELLS,” JOURNAL OF SCIENCES ISLAMIC REPUBLIC OF IRAN, vol. 13, no. 1, pp. 15–18, 2002, [Online]. Available: https://sid.ir/paper/532071/en

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