SYNTHESIS AND IN VITRO HYDROLYTIC DEGRADATION OF POLYGLYCOLIDE AND ITS L-LACTIDE COPOLYMER

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MOHAMMADI ROUSHAN DEH J.; NABI SARBOLOUKI M.

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Journal Paper

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Journal: Iranian Polymer Journal Year:2001 | Volume:10 | Issue:1 Page(s): 53-58

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Information Journal Paper

Title

SYNTHESIS AND IN VITRO HYDROLYTIC DEGRADATION OF POLYGLYCOLIDE AND ITS L-LACTIDE COPOLYMER

Author(s)

MOHAMMADI ROUSHAN DEH J. | NABI SARBOLOUKI M. | Issue Writer Certificate

Keywords

POLYGLYCOLIDE

POLY(L-LACTIDE)

IN-VITRO DEGRADATION

STANNOUS OCTOATE

Abstract

In this study homo- and copolymers of glycolide and l-lactide were synthesized and subjected to in vitro hydrolytic degradation. Glycolide and l-lactide were prepared from glycolic and l-lactic acid, respectively. STANNOUS OCTOATE was used as polymerization catalyst. Poly(l-lactide) with M-w=9.4x105 and a polydispersity of 1.89 was synthesized and characterized. Also copolymers of l-lactide and glycolide were prepared. POLYGLYCOLIDE and its lactide copolymers with high proportion of glycolide do not dissolve in organic solvents. Degradation studies were conducted at 37 degreesC and pH=7.35. The concentration of released glycolic acid was determined by chromotropic acid reagent. Purified POLYGLYCOLIDE powder shows a fast degradation profile in the first 10 days, after which it levels off. A copolymer obtained from 10 mol% l-lactide and 90 mol% glycolide shows different degradation pattern as POLYGLYCOLIDE, because of its amorphous nature it exhibits a higher degradation rate.

Cites

BIOCOMPATIBILITY AND BIODEGRADATION OF POLY (D,L-LACTIC-CO-GLYCOLIC ACID) 90/10: IN VITRO AND IN VIVO ASSAYS

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APA: Copy

MOHAMMADI ROUSHAN DEH, J., & NABI SARBOLOUKI, M.. (2001). SYNTHESIS AND IN VITRO HYDROLYTIC DEGRADATION OF POLYGLYCOLIDE AND ITS L-LACTIDE COPOLYMER . IRANIAN POLYMER JOURNAL (ENGLISH), 10(1), 53-58. SID. https://sid.ir/paper/532277/en

Vancouver: Copy

MOHAMMADI ROUSHAN DEH J., NABI SARBOLOUKI M.. SYNTHESIS AND IN VITRO HYDROLYTIC DEGRADATION OF POLYGLYCOLIDE AND ITS L-LACTIDE COPOLYMER . IRANIAN POLYMER JOURNAL (ENGLISH)[Internet]. 2001;10(1):53-58. Available from: https://sid.ir/paper/532277/en

IEEE: Copy

J. MOHAMMADI ROUSHAN DEH, and M. NABI SARBOLOUKI, “SYNTHESIS AND IN VITRO HYDROLYTIC DEGRADATION OF POLYGLYCOLIDE AND ITS L-LACTIDE COPOLYMER ,” IRANIAN POLYMER JOURNAL (ENGLISH), vol. 10, no. 1, pp. 53–58, 2001, [Online]. Available: https://sid.ir/paper/532277/en

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