HYDROGELS FOR COLON-SPECIFIC ORAL DRUG DELIVERY: AN IN VITRO DRUG RELEASE STUDY (II)

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BAJPAI S.K.; SONKUSLEY S.J.

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Journal Paper

Paper Information

Journal: Iranian Polymer Journal Year:2002 | Volume:11 | Issue:3 Page(s): 187-196

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Information Journal Paper

Title

HYDROGELS FOR COLON-SPECIFIC ORAL DRUG DELIVERY: AN IN VITRO DRUG RELEASE STUDY (II)

Author(s)

BAJPAI S.K. | SONKUSLEY S.J. | Issue Writer Certificate

Keywords

VITAMIN B2 GASTROINTESTINAL TRACT

PH-DEPENDENT RELEASE

POLY(ACRYLAMIDE-CO-MALEIC ACID) HYDROGELS

COLON

Abstract

Drug-loaded cylindrical polymer matrices, composed of poly (N-vinyl-2-pyrrolidone) and poly(acrylamide-co-maleic acid) have been synthesized and the release of vitamin B2 from these gels has been studied at the physiological temperature 37°C. The devices show strong PH-DEPENDENT RELEASE behavelour, thus offering a maximum release at pH 7.4. The initial amount of drug loaded into the device and the diameter of the cylindrical samples also affect the release kinetics. With the increase in the maleic acid content inside the device having maximum 43.0 mM, the release rate has been found to increase, whereas further increase in the acid content slows down the release rate. Finally, the release of riboflavin from the devices has been explained onthe basis of the swelling-dependent mechanism

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APA: Copy

BAJPAI, S.K., & SONKUSLEY, S.J.. (2002). HYDROGELS FOR COLON-SPECIFIC ORAL DRUG DELIVERY: AN IN VITRO DRUG RELEASE STUDY (II). IRANIAN POLYMER JOURNAL (ENGLISH), 11(3), 187-196. SID. https://sid.ir/paper/536443/en

Vancouver: Copy

BAJPAI S.K., SONKUSLEY S.J.. HYDROGELS FOR COLON-SPECIFIC ORAL DRUG DELIVERY: AN IN VITRO DRUG RELEASE STUDY (II). IRANIAN POLYMER JOURNAL (ENGLISH)[Internet]. 2002;11(3):187-196. Available from: https://sid.ir/paper/536443/en

IEEE: Copy

S.K. BAJPAI, and S.J. SONKUSLEY, “HYDROGELS FOR COLON-SPECIFIC ORAL DRUG DELIVERY: AN IN VITRO DRUG RELEASE STUDY (II),” IRANIAN POLYMER JOURNAL (ENGLISH), vol. 11, no. 3, pp. 187–196, 2002, [Online]. Available: https://sid.ir/paper/536443/en

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