SEVERE HYPERSENSITIVITY TO IONIZING RADIATION INDUCED BY LOW DOSES OF X-RAYS

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MORTAZAVI S.M.J.; IKUSHIMA T.; SHARAFI A.A.; ISHI Y.

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Journal: RESEARCH JOURNAL OF UNIVERSITY OF ISFAHAN "SCIENCE" Year:2001 | Volume:14 | Issue:2 Page(s): 67-76

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Title

SEVERE HYPERSENSITIVITY TO IONIZING RADIATION INDUCED BY LOW DOSES OF X-RAYS

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Abstract

When human, animals and plants cells arc exposed to low doses of an agent that induce DNA damages, they often become less sensitive to the detrimental effects of higher doses of those agents administered subsequently. This phenomenon has been termed an adaptive response. There is growing evidence for the existence of radioadptive response. On the other hand, some investigators have reported entirely negative results in individuals with chromosone instabilities as well as healthy persons. In our previous studies we observed a young healthy non - responder who showed a severe hypersensitivity to radiation after a low dose treatment. We selected this hypersensitive donor for a follow-up study. To assess whether this kind of hypersensitivity to ionizing radiation is a temporary situation or not, we evaluated the frequency of radiation-induced chromosome aberrations during a 6 month follow up. Peripheral blood lymphocytes of this donor were exposed to an adapting dose of 10 cGy X-rays followed hy a challenge dose of 3 Gy X-rays with different radiation qualities. Our blood donor did not show adaptive response in any experiment.Considering lack of adaptive response in all of our experiments as well as the induction of a statistically significant synergistic effect in some experiments, it may he concluded that lack of adaptive response is not a temporary situation.

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APA: Copy

MORTAZAVI, S.M.J., IKUSHIMA, T., SHARAFI, A.A., & ISHI, Y.. (2001). SEVERE HYPERSENSITIVITY TO IONIZING RADIATION INDUCED BY LOW DOSES OF X-RAYS. RESEARCH JOURNAL OF UNIVERSITY OF ISFAHAN "SCIENCE", 14(2), 67-76. SID. https://sid.ir/paper/55809/en

Vancouver: Copy

MORTAZAVI S.M.J., IKUSHIMA T., SHARAFI A.A., ISHI Y.. SEVERE HYPERSENSITIVITY TO IONIZING RADIATION INDUCED BY LOW DOSES OF X-RAYS. RESEARCH JOURNAL OF UNIVERSITY OF ISFAHAN "SCIENCE"[Internet]. 2001;14(2):67-76. Available from: https://sid.ir/paper/55809/en

IEEE: Copy

S.M.J. MORTAZAVI, T. IKUSHIMA, A.A. SHARAFI, and Y. ISHI, “SEVERE HYPERSENSITIVITY TO IONIZING RADIATION INDUCED BY LOW DOSES OF X-RAYS,” RESEARCH JOURNAL OF UNIVERSITY OF ISFAHAN "SCIENCE", vol. 14, no. 2, pp. 67–76, 2001, [Online]. Available: https://sid.ir/paper/55809/en

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