PRODUCTION OF EFFECTIVE ANTIVENIN TO TREAT COBRA SNAKE (NAJA NAJA OXIANA) ENVENOMING

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AKBARI A.; RABIEI H.; HEDAYAT A.; MOHAMMADPOUR N.; ZOU ALFAGHARI HASAN; TEYMOURZADEH SH.

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Journal Paper

Paper Information

Journal: ARCHIVES OF RAZI INSTITUTE Year:2010 | Volume:65 | Issue:1 Page(s): 33-37

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Title

PRODUCTION OF EFFECTIVE ANTIVENIN TO TREAT COBRA SNAKE (NAJA NAJA OXIANA) ENVENOMING

Author(s)

Keywords

NAJA NAJA OXIANA

VENOM

GEL CHROMATOGRAPHY

ANTIVENIN

Abstract

Conventional treatment of Naja naja oxiana (NNO) envenoming requires large volumes of equine antivenin raised against NNO crude venom. The poor efficiency of this antivenin is assumed to be due to the high molecular weight non-toxic proteins, a strong immunogen, present in the crude venom. These proteins cause depression of antibody formation against the low molecular weight toxic components of venom. In the present study the low molecular weight lethal components were isolated from crude venom of NNO venom by sephadex G50 get filtration chromatography. A sera was prepared by immunizing horses with toxic fraction. One milliliter of this serum neutralized 1.8mg of NNO crude venom. This high titer antivenin is thus 2.2 times more potent than the sera obtained against NNO crude venom.

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APA: Copy

AKBARI, A., RABIEI, H., HEDAYAT, A., MOHAMMADPOUR, N., ZOU ALFAGHARI, HASAN, & TEYMOURZADEH, SH.. (2010). PRODUCTION OF EFFECTIVE ANTIVENIN TO TREAT COBRA SNAKE (NAJA NAJA OXIANA) ENVENOMING. ARCHIVES OF RAZI INSTITUTE, 65(1), 33-37. SID. https://sid.ir/paper/571718/en

Vancouver: Copy

AKBARI A., RABIEI H., HEDAYAT A., MOHAMMADPOUR N., ZOU ALFAGHARI HASAN, TEYMOURZADEH SH.. PRODUCTION OF EFFECTIVE ANTIVENIN TO TREAT COBRA SNAKE (NAJA NAJA OXIANA) ENVENOMING. ARCHIVES OF RAZI INSTITUTE[Internet]. 2010;65(1):33-37. Available from: https://sid.ir/paper/571718/en

IEEE: Copy

A. AKBARI, H. RABIEI, A. HEDAYAT, N. MOHAMMADPOUR, HASAN ZOU ALFAGHARI, and SH. TEYMOURZADEH, “PRODUCTION OF EFFECTIVE ANTIVENIN TO TREAT COBRA SNAKE (NAJA NAJA OXIANA) ENVENOMING,” ARCHIVES OF RAZI INSTITUTE, vol. 65, no. 1, pp. 33–37, 2010, [Online]. Available: https://sid.ir/paper/571718/en

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