THE EFFECT OF PERIPHERAL AND CENTRAL ADMINISTRATION MONOSIALOGANGLIOSIDE GM1 ON LEARNING AND MEMORY OF YOUNG AND ADULT RATS

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MOAZEDI A.A.; NASRI NASRABADI M.; CHINIPARDAZ R.

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Paper Information

Journal: SHAHID CHAMRAN UNIVERSITY JOURNAL OF SCIENCE Year:2003 | Volume:NEW SERIES | Issue:11 (SECTION B) Page(s): 71-86

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Title

THE EFFECT OF PERIPHERAL AND CENTRAL ADMINISTRATION MONOSIALOGANGLIOSIDE GM1 ON LEARNING AND MEMORY OF YOUNG AND ADULT RATS

Author(s)

MOAZEDI A.A. | NASRI NASRABADI M. | CHINIPARDAZ R. | Issue Writer Certificate

Keywords

MONOSIALOGANGLIOSIDEQ4

GM1Q4

LEARNING AND MEMORYQ4

SHUTTLE BOXQ4

RATQ4

Abstract

MONOSIALOGANGLIOSIDE GMI has been found to be abundant in various regions of the mammalian central nervous system. Numerous investigations have indicated the involvement of ganglioside in neurobiological events associated with adaptive with adaptive functions, neuronal plasticity and formation of memory. The present study investigates the effects of peripheral and central administration of GM1on LEARNING AND MEMORY of 1.5 months old (young) or 8 month old (adult) RATs tested in passive avoidance task, by SHUTTLE BOX. Two parameteres, including age and injection type have been considered in this work. The injection was done both intraperitonealy (ip) and intracerebrovntricular (icv). The result indicates that the young RATs received GMI (2mglkg ip) improved their retention after one month of training compare to those which received saline. But, the young RATs which received GMI (100 nm/10 mlit icv) didn't improve their retention on the whole behavioral test. Also, the GMI administration had no effect on LEARNING AND MEMORY of adult RATs and no improved retention was observed in all of the sessions. In conclusion, treatment with GM1 intraperitonealy increases memory in young RATs, and this suggests a possible action of GMI on the maturation of the central nervous system.

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References

اثر مونوسیالوگانگلیوزید GM1 بر یادگیری تشخیصی در موش صحرایی با استفاده از Y-maze

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APA: Copy

MOAZEDI, A.A., NASRI NASRABADI, M., & CHINIPARDAZ, R.. (2003). THE EFFECT OF PERIPHERAL AND CENTRAL ADMINISTRATION MONOSIALOGANGLIOSIDE GM1 ON LEARNING AND MEMORY OF YOUNG AND ADULT RATS. SHAHID CHAMRAN UNIVERSITY JOURNAL OF SCIENCE, NEW SERIES(11 (SECTION B)), 71-86. SID. https://sid.ir/paper/58013/en

Vancouver: Copy

MOAZEDI A.A., NASRI NASRABADI M., CHINIPARDAZ R.. THE EFFECT OF PERIPHERAL AND CENTRAL ADMINISTRATION MONOSIALOGANGLIOSIDE GM1 ON LEARNING AND MEMORY OF YOUNG AND ADULT RATS. SHAHID CHAMRAN UNIVERSITY JOURNAL OF SCIENCE[Internet]. 2003;NEW SERIES(11 (SECTION B)):71-86. Available from: https://sid.ir/paper/58013/en

IEEE: Copy

A.A. MOAZEDI, M. NASRI NASRABADI, and R. CHINIPARDAZ, “THE EFFECT OF PERIPHERAL AND CENTRAL ADMINISTRATION MONOSIALOGANGLIOSIDE GM1 ON LEARNING AND MEMORY OF YOUNG AND ADULT RATS,” SHAHID CHAMRAN UNIVERSITY JOURNAL OF SCIENCE, vol. NEW SERIES, no. 11 (SECTION B), pp. 71–86, 2003, [Online]. Available: https://sid.ir/paper/58013/en

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