SHORT COMMUNICATION: EXPRESSION OF CYTOCHROME P450 AND GLUTATHIONE S-TRANSFERASE IN HUMAN BONE MARROW MESENCHYMAL STEM CELLS

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ESMAELI SHAHNAZ; ALLAMEH ABDOLAMIR; EMAMI AL AGHA MOHAMMAD SAJAD; KAZEMNEJAD SOMAYE; SOLEIMANI MASOUD

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Journal: Iranian Journal of Biotechnology Year:2012 | Volume:10 | Issue:4 Page(s): 270-274

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Title

SHORT COMMUNICATION: EXPRESSION OF CYTOCHROME P450 AND GLUTATHIONE S-TRANSFERASE IN HUMAN BONE MARROW MESENCHYMAL STEM CELLS

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Keywords

HUMAN BONE MARROW MESENCHYMAL STEM CELLS

DRUG METABOLISM

GLUTATHIONE S-TRANSFERASES

CYTOCHROME P450

Abstract

Currently several studies are being carried out on various properties of mesenchymal stem cells (MSCs) however there are a few investigations about drug metabolizing properties of these cells. The aim of this study was to measure the key factors involved in DRUG METABOLISM in human bone marrow MSCs. For this purpose, cellular glutathione (GSH), glutathione Stransferase (GSTs) and CYTOCHROME P450 class 3A4 (CYP3A4) were detected in these cells. Results showed that CYP3A4 and GSTA1-1 mRNA are not detectable in MSCs however mRNA specific for GSTP1-1 was considerably expressed in MSCs. GSH content and GST activity was also detected in MSCs.These data suggest that human bone marrow MSCs possess the drug metabolizing activity which may be useful in handling drugs and chemotherapeutic agents passing to the bone marrow.

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APA: Copy

ESMAELI, SHAHNAZ, ALLAMEH, ABDOLAMIR, EMAMI AL AGHA, MOHAMMAD SAJAD, KAZEMNEJAD, SOMAYE, & SOLEIMANI, MASOUD. (2012). SHORT COMMUNICATION: EXPRESSION OF CYTOCHROME P450 AND GLUTATHIONE S-TRANSFERASE IN HUMAN BONE MARROW MESENCHYMAL STEM CELLS. IRANIAN JOURNAL OF BIOTECHNOLOGY, 10(4), 270-274. SID. https://sid.ir/paper/586398/en

Vancouver: Copy

ESMAELI SHAHNAZ, ALLAMEH ABDOLAMIR, EMAMI AL AGHA MOHAMMAD SAJAD, KAZEMNEJAD SOMAYE, SOLEIMANI MASOUD. SHORT COMMUNICATION: EXPRESSION OF CYTOCHROME P450 AND GLUTATHIONE S-TRANSFERASE IN HUMAN BONE MARROW MESENCHYMAL STEM CELLS. IRANIAN JOURNAL OF BIOTECHNOLOGY[Internet]. 2012;10(4):270-274. Available from: https://sid.ir/paper/586398/en

IEEE: Copy

SHAHNAZ ESMAELI, ABDOLAMIR ALLAMEH, MOHAMMAD SAJAD EMAMI AL AGHA, SOMAYE KAZEMNEJAD, and MASOUD SOLEIMANI, “SHORT COMMUNICATION: EXPRESSION OF CYTOCHROME P450 AND GLUTATHIONE S-TRANSFERASE IN HUMAN BONE MARROW MESENCHYMAL STEM CELLS,” IRANIAN JOURNAL OF BIOTECHNOLOGY, vol. 10, no. 4, pp. 270–274, 2012, [Online]. Available: https://sid.ir/paper/586398/en

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