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Title

THE EFFECTS OF ETHANOL EXTRACT OF PROPOLIS (EEP) ON THE EXPERIMENTALLY INDUCED CANDIDA KERATITIS IN RABBITS

Pages

  22-27

Abstract

 Background: PROPOLIS (bee glue) is a resinous substance obtained from bee hives living on various plant sources. The purpose of this study was to evaluate the effects of ETHANOL EXTRACT of PROPOLIS (EEP) on the experimentally induced Candidial KERATITIS in RABBITs.Methods: The alcoholic EXTRACT of PROPOLIS was prepared by 80% ethyl alcohol. After suppressing the immune system of 24 male RABBITs, experimental CANDIDA ALBICANS KERATITIS was induced in the animals under local anesthesia and sterile conditions. The animals were later divided into four groups including the control or glycerin group and a NYSTATIN and two 500 and 1000ig/ml EEP groups. Treatment continued for 21 days and after sacrificing the animals by humane methods, histopathological samples of the RABBITs’ eyes were prepared.Results: KERATITIS was developed in the eyes of all RABBITs a week after the yeast inoculation. In the control group in which animals received glycerin, KERATITIS persisted until day 21. Clinical signs of KERATITIS disappeared in the NYSTATIN and 1000ig/ml EEP groups after 14 and 21 days, respectively. The clinical signs of KERATITIS partially ameliorated in the animals receiving 500ig/ml EEP. Histopathological examination revealed no differences between groups receiving NYSTATIN or 1000ig/ml EEP.Conclusion: It is concluded that, ETHANOL EXTRACT of PROPOLIS could completely treat CANDIDA ALBICANS KERATITIS in 1000ìg/ml concentrations. This EXTRACT can be used as a safe antifungal agent against CANDIDA ALBICANS and it is a good substitute for synthetic antifungal agents like NYSTATIN.

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    APA: Copy

    AHANGARI, ALI ASGHAR, OWNAGH, ABDULGHAFFAR, TEHRANI, ALI ASGHAR, & TUKMECHI, AMIR. (2011). THE EFFECTS OF ETHANOL EXTRACT OF PROPOLIS (EEP) ON THE EXPERIMENTALLY INDUCED CANDIDA KERATITIS IN RABBITS. AMIRKABIR, 69(1), 22-27. SID. https://sid.ir/paper/587515/en

    Vancouver: Copy

    AHANGARI ALI ASGHAR, OWNAGH ABDULGHAFFAR, TEHRANI ALI ASGHAR, TUKMECHI AMIR. THE EFFECTS OF ETHANOL EXTRACT OF PROPOLIS (EEP) ON THE EXPERIMENTALLY INDUCED CANDIDA KERATITIS IN RABBITS. AMIRKABIR[Internet]. 2011;69(1):22-27. Available from: https://sid.ir/paper/587515/en

    IEEE: Copy

    ALI ASGHAR AHANGARI, ABDULGHAFFAR OWNAGH, ALI ASGHAR TEHRANI, and AMIR TUKMECHI, “THE EFFECTS OF ETHANOL EXTRACT OF PROPOLIS (EEP) ON THE EXPERIMENTALLY INDUCED CANDIDA KERATITIS IN RABBITS,” AMIRKABIR, vol. 69, no. 1, pp. 22–27, 2011, [Online]. Available: https://sid.ir/paper/587515/en

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