THE EFFECT OF POLYLACTIC ACID SUPPORT IN STABILITY AND ELECTRICAL FIELD OF HETEROCYCLIC COUPLED HEXA PEPTIDE NANO SYSTEMS: A NOVEL STRATEGY TO DRUG DELIVERY

Q: How can I download an article?

To download an article from SID, first log in to the site, search for the article title, and click on the 'Download Article' option.

Q: How can I download an ISI article?

To download an ISI article on SID, enter the keyword or article title in the search bar, view the relevant results, click on the desired article, and select the 'Download Article' option.

Q: How can I access the SID database?

To access the SID database, visit SID.ir, create an account, and log in to access scientific resources.

Q: Is downloading articles from SID free?

Some articles on SID are available for free, while others require payment. Details are specified on the article's page.

KHALILI HADAD B.; MONAJJEMI M.

مرکز اطلاعات علمی Scientific Information Database (SID) - Trusted Source for Research and Academic Resources

Journal Paper

Paper Information

Journal: JOURNAL OF PHYSICAL AND THEORETICAL CHEMISTRY Year:2010 | Volume:7 | Issue:2 Page(s): 63-71

Download Full-Text

View:

290

Download:

Cites:

Information Journal Paper

Title

THE EFFECT OF POLYLACTIC ACID SUPPORT IN STABILITY AND ELECTRICAL FIELD OF HETEROCYCLIC COUPLED HEXA PEPTIDE NANO SYSTEMS: A NOVEL STRATEGY TO DRUG DELIVERY

Author(s)

KHALILI HADAD B. | MONAJJEMI M. | Issue Writer Certificate

Keywords

CYCLO HEXA PEPTIDE NANO RING

DRUG DELIVERY

QUANTUM MECHANICS

POLYLACTIC ACID

GIBBS FREE ENERGY

DIPOLE MOMENT

Abstract

Biological materials, recently, are the building blocks of several self-assembling peptide and protein systems.The main challenge in molecular self-assembly is to design molecular building blocks that can undergo spontaneous organization. These cyclic peptides were produced by an alternating even number of D- and Lamino acids, which interact through non-covalent interactions to an array of selfassembled nanotubes.Physicochemical properties of structure of some peptide nanorings in couple form, with the support of a biocompatible and biodegradable POLYLACTIC ACID, (PLA) have been calculated by quantum mechanical calculations within the Onsager self-consistent reaction field (SCRF) model using a Hartree-Fock method (RHF) at the RHF/STO-3G (5D-7F) level in water medium at 310 K. Four rings, Cyclo [-(D-Gly-L-Gly)3] (A), Cyclo[-(D-Gly-L-Ala)3] (B), Cyclo [-(D-Gly-L-aminoGly)3] (C), Cyclo [-(D-Gly-L-hydroxyGly)3] (D), are designed in a couple form and geometrically optimized near by the 1, 3 and 6 POLYLACTIC ACID, (PLA) support, with non-covalent interaction. Analyzing the geometrical position of POLYLACTIC ACID chain, around the coupled nano system, results the PLA is preferred to stand in the distance of 4 A of AA, 2-5 A for AB and 12 A for both BC and AD. The stability of some systems, could not be affected in the wide range of distances such as, AC in 1-10 A, BB in 3-12 A, CC in 4-12 A and both CD and DD in the 2-12 A. DD nano system presents the best in all conditions where CC, BD and AD couples stand in the second rank BC and AC stand after. The stability of AA, AB and BB are less. Although no effect in behavior of nano systems are seen, increasing the number of supports make them more stable. Coming near and go far, the PLA affects the DIPOLE MOMENT of system, deeply.

Cites

No record.

References

Cite

APA: Copy

KHALILI HADAD, B., & MONAJJEMI, M.. (2010). THE EFFECT OF POLYLACTIC ACID SUPPORT IN STABILITY AND ELECTRICAL FIELD OF HETEROCYCLIC COUPLED HEXA PEPTIDE NANO SYSTEMS: A NOVEL STRATEGY TO DRUG DELIVERY. JOURNAL OF PHYSICAL AND THEORETICAL CHEMISTRY, 7(2), 63-71. SID. https://sid.ir/paper/587937/en

Vancouver: Copy

KHALILI HADAD B., MONAJJEMI M.. THE EFFECT OF POLYLACTIC ACID SUPPORT IN STABILITY AND ELECTRICAL FIELD OF HETEROCYCLIC COUPLED HEXA PEPTIDE NANO SYSTEMS: A NOVEL STRATEGY TO DRUG DELIVERY. JOURNAL OF PHYSICAL AND THEORETICAL CHEMISTRY[Internet]. 2010;7(2):63-71. Available from: https://sid.ir/paper/587937/en

IEEE: Copy

B. KHALILI HADAD, and M. MONAJJEMI, “THE EFFECT OF POLYLACTIC ACID SUPPORT IN STABILITY AND ELECTRICAL FIELD OF HETEROCYCLIC COUPLED HEXA PEPTIDE NANO SYSTEMS: A NOVEL STRATEGY TO DRUG DELIVERY,” JOURNAL OF PHYSICAL AND THEORETICAL CHEMISTRY, vol. 7, no. 2, pp. 63–71, 2010, [Online]. Available: https://sid.ir/paper/587937/en

Related Journal Papers

No record.

Related Seminar Papers

No record.

Related Plans

No record.

Recommended Workshops