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Information Journal Paper

Title

PROBING OF THE INTERACTION BETWEEN HUMAN SERUM ALBUMIN AND A NEW SYNTHESIZED PD (II) COMPLEX USING SPECTROSCOPIC METHODS

Pages

  105-111

Keywords

HAS 
PD (II) COMPLEX 

Abstract

 Human serum albumin (HSA) is an abundant, multifunctional and nonglycosylated negatively charged plasma protein. HSA ascribed ligand-binding and transport properties, antioxidant functions and enzymatic activities. In the present study, the interaction and SIDE EFFECTs of a new designed anti-cancer compound (1, 10-phenanthroline butyl dithiocarbamato palladium (II) nitrate) on HSA have been investigated by different spectroscopic (UV-visible, FLUORESCENCE and CIRCULAR DICHROISM (CD)) techniques at two temperatures of 25 and 37oC. By the analysis of FLUORESCENCE spectra, it was observed that this complex HAS an ability to quench the intrinsic FLUORESCENCE of HSA through a static quenching procedure. The number of binding sites and the association binding constants of Pd (II) complex were calculated at 25 and 37oC. Also, the negative DHo and positive DSo values for the interaction calculated by the vant’s Hoff equation showed that the electrostatic interaction HAS a major role in the binding process. The quantitative analysis of CD spectra represented that Pd (II) complex induces significantly alterations in the secondary structure of HSAvia decreasing in the content of a helical structure of the protein. Our results suggest that the new synthesized Pd (II) complex can bind to the blood carrier protein of HSA and change the tertiary and secondary structure of the protein, which may be considered as SIDE EFFECTs of this new synthesized drug.

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    • Cite

    APA: Copy

    DIVSALAR, A., KHODABAKHSHIAN, S., SABOURI, A.A., MANSOURI TORSHIZI, H., & EVINI, M.. (2013). PROBING OF THE INTERACTION BETWEEN HUMAN SERUM ALBUMIN AND A NEW SYNTHESIZED PD (II) COMPLEX USING SPECTROSCOPIC METHODS. JOURNAL OF SCIENCES ISLAMIC REPUBLIC OF IRAN, 24(2), 105-111. SID. https://sid.ir/paper/595397/en

    Vancouver: Copy

    DIVSALAR A., KHODABAKHSHIAN S., SABOURI A.A., MANSOURI TORSHIZI H., EVINI M.. PROBING OF THE INTERACTION BETWEEN HUMAN SERUM ALBUMIN AND A NEW SYNTHESIZED PD (II) COMPLEX USING SPECTROSCOPIC METHODS. JOURNAL OF SCIENCES ISLAMIC REPUBLIC OF IRAN[Internet]. 2013;24(2):105-111. Available from: https://sid.ir/paper/595397/en

    IEEE: Copy

    A. DIVSALAR, S. KHODABAKHSHIAN, A.A. SABOURI, H. MANSOURI TORSHIZI, and M. EVINI, “PROBING OF THE INTERACTION BETWEEN HUMAN SERUM ALBUMIN AND A NEW SYNTHESIZED PD (II) COMPLEX USING SPECTROSCOPIC METHODS,” JOURNAL OF SCIENCES ISLAMIC REPUBLIC OF IRAN, vol. 24, no. 2, pp. 105–111, 2013, [Online]. Available: https://sid.ir/paper/595397/en

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