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Title

TERMINATION OF NOCICEPTIVE BAHAVIOUR AT THE END OF PHASE 2 OF FORMALIN TEST IS ATTRIBUTABLE TO ENDOGENOUS INHIBITORY MECHANISMS, BUT NOT BY OPIOID RECEPTORS ACTIVATION

Pages

  48-54

Abstract

   Introduction: Formalin injection induces nociceptive bahaviour in phase I and II, with a quiescent phase between them. While active inhibitory mechanisms are proposed to be responsible for initiation of interphase, the exact mechanisms which lead to termination of nociceptive response in phase II are not clear yet. Phase II is a consequence of peripheral and central sensitization processes, which can lead to termination of the noxious stimuli responses; 45-60 minutes after formalin injection via possible recruitment of active inhibitory mechanisms which we have investigated in this study.Methods: To test our hypothesis, in the first set of experiments, we evaluated nociceptive response after two consecutive injection of formalin (50mL, 2%), with intervals of 5 or 60 minutes. In the next set, FORMALIN TESTs were carried out in companion with injection of NALOXONE Hydrochloride, a non-selective antagonist of opioid receptors, pre-formalin injection and 30 and 45 minutes post formalin injection.Results: While normal nociceptive behaviour was observed in the group receiving one injection of formalin, a diminished response was observed in phases I and II of those receiving consequent injection of formalin, 60 minute after first injection. While second injection of formalin, 5 minute after first injection, had no effect. Administration of NALOXONE (1mg/kg) decreased NOCICEPTION in phase 2A; but had no effect on delayed termination of FORMALIN TEST.Discussion: The results of this study suggest the existence of an active inhibitory mechanism, other than the endogenous opioids, that is responsible for termination of nociceptive behavior at the end of FORMALIN TEST.

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    APA: Copy

    AZHDARI ZARMEHRI, HASSAN, MOHAMMAD ZADEH, MOHAMMAD, FERIDONI, MASOUD, & NAZERI, MASOUD. (2014). TERMINATION OF NOCICEPTIVE BAHAVIOUR AT THE END OF PHASE 2 OF FORMALIN TEST IS ATTRIBUTABLE TO ENDOGENOUS INHIBITORY MECHANISMS, BUT NOT BY OPIOID RECEPTORS ACTIVATION. VIRTUAL, 5(1), 48-54. SID. https://sid.ir/paper/620941/en

    Vancouver: Copy

    AZHDARI ZARMEHRI HASSAN, MOHAMMAD ZADEH MOHAMMAD, FERIDONI MASOUD, NAZERI MASOUD. TERMINATION OF NOCICEPTIVE BAHAVIOUR AT THE END OF PHASE 2 OF FORMALIN TEST IS ATTRIBUTABLE TO ENDOGENOUS INHIBITORY MECHANISMS, BUT NOT BY OPIOID RECEPTORS ACTIVATION. VIRTUAL[Internet]. 2014;5(1):48-54. Available from: https://sid.ir/paper/620941/en

    IEEE: Copy

    HASSAN AZHDARI ZARMEHRI, MOHAMMAD MOHAMMAD ZADEH, MASOUD FERIDONI, and MASOUD NAZERI, “TERMINATION OF NOCICEPTIVE BAHAVIOUR AT THE END OF PHASE 2 OF FORMALIN TEST IS ATTRIBUTABLE TO ENDOGENOUS INHIBITORY MECHANISMS, BUT NOT BY OPIOID RECEPTORS ACTIVATION,” VIRTUAL, vol. 5, no. 1, pp. 48–54, 2014, [Online]. Available: https://sid.ir/paper/620941/en

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