SHORT PAPER: EFFECTS OF CO-ADMINISTRATION OF GHRELIN AGONIST (GHRP-2) AND GH ON TNF-α, IL-6 AND INOS GENE EXPRESSION INDUCED BY LPS IN THE MOUSE BRAIN

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ZENDEHDEL M.; ALLAHDINI P.; SAFARPOUR E.; ABREHDARI Z.; POURRAHIMI M.; MAZAHERINEZHAD FARD R.

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Journal: IRANIAN JOURNAL OF VETERINARY RESEARCH (IJVR) Year:2013 | Volume:14 | Issue:4 (45) Page(s): 341-344

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Title

SHORT PAPER: EFFECTS OF CO-ADMINISTRATION OF GHRELIN AGONIST (GHRP-2) AND GH ON TNF-α, IL-6 AND INOS GENE EXPRESSION INDUCED BY LPS IN THE MOUSE BRAIN

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Keywords

LPS

GHRP-2

BRAIN

MOUSE

Abstract

The aim of this study was to examine the anti-inflammatory effects of co-administration of growth hormone-releasing peptide-2 (GHRP-2) and growth hormone (GH) on tumor necrosis factor-a (TNF-a), interleukin-6 (IL-6) and inducible nitric oxide synthase (iNOS) gene expression induced by LPS in the MOUSE BRAIN. Thirty-five male NMRI mice (25±5 g) were injected through the MOUSE tail vein with saline, GHRP 2/fa?page=1&sort=1&ftyp=all&fgrp=all&fyrs=all" target="_blank"> GHRP-2 (100 mg/kg), GH (25 mg/kg) or GHRP 2/fa?page=1&sort=1&ftyp=all&fgrp=all&fyrs=all" target="_blank"> GHRP-2+GH, 30 min before the intraperitoneal injection of LPS (5 mg/kg).Then, inflammation was induced by the intraperitoneal injection of LPS. The control animals received sterile saline in the first and second injections. Changes in the expression level of TNF-a, IL-6 and iNOS genes were studied in the MOUSE BRAIN by a semi quantitative RT-PCR method. The results of this study showed that GHRP 2/fa?page=1&sort=1&ftyp=all&fgrp=all&fyrs=all" target="_blank"> GHRP-2 or GH significantly decreased the expression of TNF-a and IL-6 genes in BRAIN 2 h after the injection of LPS. Co-administration of GHRP 2/fa?page=1&sort=1&ftyp=all&fgrp=all&fyrs=all" target="_blank"> GHRP-2 and GH markedly reduced the expression of TNF-a and IL-6 genes. LPS had no effect on the expression of iNOS gene in BRAIN. The data suggest that co-administration of GHRP 2/fa?page=1&sort=1&ftyp=all&fgrp=all&fyrs=all" target="_blank"> GHRP-2 and GH has a protective effect in BRAIN inflammation induced by LPS through inhibition of TNF-αand IL-6.

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APA: Copy

ZENDEHDEL, M., ALLAHDINI, P., SAFARPOUR, E., ABREHDARI, Z., POURRAHIMI, M., & MAZAHERINEZHAD FARD, R.. (2013). SHORT PAPER: EFFECTS OF CO-ADMINISTRATION OF GHRELIN AGONIST (GHRP-2) AND GH ON TNF-α, IL-6 AND INOS GENE EXPRESSION INDUCED BY LPS IN THE MOUSE BRAIN. IRANIAN JOURNAL OF VETERINARY RESEARCH (IJVR), 14(4 (45)), 341-344. SID. https://sid.ir/paper/678886/en

Vancouver: Copy

ZENDEHDEL M., ALLAHDINI P., SAFARPOUR E., ABREHDARI Z., POURRAHIMI M., MAZAHERINEZHAD FARD R.. SHORT PAPER: EFFECTS OF CO-ADMINISTRATION OF GHRELIN AGONIST (GHRP-2) AND GH ON TNF-α, IL-6 AND INOS GENE EXPRESSION INDUCED BY LPS IN THE MOUSE BRAIN. IRANIAN JOURNAL OF VETERINARY RESEARCH (IJVR)[Internet]. 2013;14(4 (45)):341-344. Available from: https://sid.ir/paper/678886/en

IEEE: Copy

M. ZENDEHDEL, P. ALLAHDINI, E. SAFARPOUR, Z. ABREHDARI, M. POURRAHIMI, and R. MAZAHERINEZHAD FARD, “SHORT PAPER: EFFECTS OF CO-ADMINISTRATION OF GHRELIN AGONIST (GHRP-2) AND GH ON TNF-α, IL-6 AND INOS GENE EXPRESSION INDUCED BY LPS IN THE MOUSE BRAIN,” IRANIAN JOURNAL OF VETERINARY RESEARCH (IJVR), vol. 14, no. 4 (45), pp. 341–344, 2013, [Online]. Available: https://sid.ir/paper/678886/en

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