SIMULATION OF SEPARATION OF A RACEMIC MIXTURE OF IBUPROFEN BY SUPERCRITICAL FLUID CHROMATOGRAPHY IN SIMULATED MOVING BED

Q: How can I download an article?

To download an article from SID, first log in to the site, search for the article title, and click on the 'Download Article' option.

Q: How can I download an ISI article?

To download an ISI article on SID, enter the keyword or article title in the search bar, view the relevant results, click on the desired article, and select the 'Download Article' option.

Q: How can I access the SID database?

To access the SID database, visit SID.ir, create an account, and log in to access scientific resources.

Q: Is downloading articles from SID free?

Some articles on SID are available for free, while others require payment. Details are specified on the article's page.

Yazdian Kashani Sepideh; FARHADI FATHOLLAH

مرکز اطلاعات علمی Scientific Information Database (SID) - Trusted Source for Research and Academic Resources

Journal Paper

Paper Information

Journal: Journal of Chemical and Petroleum Engineering Year:2017 | Volume:51 | Issue:2 Page(s): 123-133

Download Full-Text

View:

185

Download:

188

Cites:

Information Journal Paper

Title

SIMULATION OF SEPARATION OF A RACEMIC MIXTURE OF IBUPROFEN BY SUPERCRITICAL FLUID CHROMATOGRAPHY IN SIMULATED MOVING BED

Author(s)

Yazdian Kashani Sepideh | FARHADI FATHOLLAH | Issue Writer Certificate

Keywords

ADSORPTION

IBUPROFEN

SEPARATION

SIMULATED MOVING BED

PROCESS SIMULATION

Abstract

Separation of a racemic mixture of IBUPROFEN at a low concentration level by supercritical fluid chromatography in a SIMULATED MOVING BED (SFC-SMB) is investigated by simulation. The feasibility of IBUPROFEN enantiomers SEPARATION has been experimentally examined in the literature. Our simulation results show that SEPARATION of IBUPROFEN enantiomers is feasible by this method, and R-ibuprofen and S-ibuprofen products with purity of over 99% can be obtained, which agrees with experimental data in the literature. For initial studies, the triangular theory is used to find the operating conditions. This simulation shows that the application of the triangular diagram is valuable in cases where none of the operating conditions is available. The operating point conditions, such as streams flow rates and switching time, are obtained with this method. Also, the effect of the location of the selected operating points in the triangular diagram on operating conditions, purity, and concentration of the products are investigated. In triangle theory, the optimal operating point should be near the vertex of the triangle diagram with a safety margin, to obtain products with high purity. The simulation also confirms that selecting the operating point away from the vertex of the triangular diagram will lead to diluted products.

Cites

No record.

References

No record.

Cite

APA: Copy

Yazdian Kashani, Sepideh, & FARHADI, FATHOLLAH. (2017). SIMULATION OF SEPARATION OF A RACEMIC MIXTURE OF IBUPROFEN BY SUPERCRITICAL FLUID CHROMATOGRAPHY IN SIMULATED MOVING BED. JOURNAL OF CHEMICAL AND PETROLEUM ENGINEERING (JOURNAL OF FACULTY OF ENGINEERING), 51(2), 123-133. SID. https://sid.ir/paper/708386/en

Vancouver: Copy

Yazdian Kashani Sepideh, FARHADI FATHOLLAH. SIMULATION OF SEPARATION OF A RACEMIC MIXTURE OF IBUPROFEN BY SUPERCRITICAL FLUID CHROMATOGRAPHY IN SIMULATED MOVING BED. JOURNAL OF CHEMICAL AND PETROLEUM ENGINEERING (JOURNAL OF FACULTY OF ENGINEERING)[Internet]. 2017;51(2):123-133. Available from: https://sid.ir/paper/708386/en

IEEE: Copy

Sepideh Yazdian Kashani, and FATHOLLAH FARHADI, “SIMULATION OF SEPARATION OF A RACEMIC MIXTURE OF IBUPROFEN BY SUPERCRITICAL FLUID CHROMATOGRAPHY IN SIMULATED MOVING BED,” JOURNAL OF CHEMICAL AND PETROLEUM ENGINEERING (JOURNAL OF FACULTY OF ENGINEERING), vol. 51, no. 2, pp. 123–133, 2017, [Online]. Available: https://sid.ir/paper/708386/en

Related Journal Papers

No record.

Related Seminar Papers

No record.

Related Plans

No record.

Recommended Workshops