EFFECTS OF 3 - METHYL CHOLANTHEREN ON LIVER MICROSOMAL MIXED FUNCTION OXIDASE ACTIVITIES OF ACIPENSER PERSICUS

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KARIMZADEH K.; MOSTAFAIE A.; ESMAEILI SARI A.; POURKAZEMI MOHAMMAD; ZAHMATKESH A.

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Journal: JOURNAL OF MARINE SCIENCES AND TECHNOLOGY Year:2003 | Volume:2 | Issue:4 Page(s): 71-80

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Title

EFFECTS OF 3 - METHYL CHOLANTHEREN ON LIVER MICROSOMAL MIXED FUNCTION OXIDASE ACTIVITIES OF ACIPENSER PERSICUS

Author(s)

Keywords

MIXED FUNCTION OXIDASEQ4

ETHOXYRESORUFIN-O DEETHYLASE(EROO)Q4

CYTOCHROME P4501AQ4

ACIPENSER PERSICUSQ4

Abstract

The microsomal cytochrome P450 dependent MIXED FUNCTION OXIDASE systemes is responsible to catalyze the first step of chemical Biotransformation. In this research the inducing effects of 3- Methyl Cholantheren were studied in ACIPENSER PERSICUS microsomal MIXED FUNCTION OXIDASE. Fish were received 3- MethylCholantheren at doses about 20 and 40 mg/kg body weight/day i.p.for 3days respectively. In treatment fish did not observe any significant changes in anilin 4 –hydroxylase and NADPH - cytochrome C reductase, but 3 - Methylcholantheren treatment caused a 20 - 25 fold increase in 7 - Ethoxyresorufin- O-deethylase (EROD) activity of fish liver microsome.Acipenser persicus liver microsomal EROD activity was investigated with respect to substrate concentation, amount of enzyme, incubation period and temperature. SOS -PAGE of microsomal protein pattern was showed that there is a protein with molecular mass of 58±1 KDa. So induction effect of 3 -Methylcholantheren could be induced isoenzyme P4501A. and is increased the isoenzyme biosynthysis.

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APA: Copy

KARIMZADEH, K., MOSTAFAIE, A., ESMAEILI SARI, A., POURKAZEMI, MOHAMMAD, & ZAHMATKESH, A.. (2003). EFFECTS OF 3 - METHYL CHOLANTHEREN ON LIVER MICROSOMAL MIXED FUNCTION OXIDASE ACTIVITIES OF ACIPENSER PERSICUS. JOURNAL OF MARINE SCIENCES AND TECHNOLOGY, 2(4), 71-80. SID. https://sid.ir/paper/74551/en

Vancouver: Copy

KARIMZADEH K., MOSTAFAIE A., ESMAEILI SARI A., POURKAZEMI MOHAMMAD, ZAHMATKESH A.. EFFECTS OF 3 - METHYL CHOLANTHEREN ON LIVER MICROSOMAL MIXED FUNCTION OXIDASE ACTIVITIES OF ACIPENSER PERSICUS. JOURNAL OF MARINE SCIENCES AND TECHNOLOGY[Internet]. 2003;2(4):71-80. Available from: https://sid.ir/paper/74551/en

IEEE: Copy

K. KARIMZADEH, A. MOSTAFAIE, A. ESMAEILI SARI, MOHAMMAD POURKAZEMI, and A. ZAHMATKESH, “EFFECTS OF 3 - METHYL CHOLANTHEREN ON LIVER MICROSOMAL MIXED FUNCTION OXIDASE ACTIVITIES OF ACIPENSER PERSICUS,” JOURNAL OF MARINE SCIENCES AND TECHNOLOGY, vol. 2, no. 4, pp. 71–80, 2003, [Online]. Available: https://sid.ir/paper/74551/en

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