Synthesis, Characterization, and Study of Anti-Tubercular and Anti-Microbial Activity of Isonicotinohydrazide Tridentate Schiff Base Ligands

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PAHLAVANI ELHAM; KARGAR HADI

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Journal: Iranian Journal of Chemistry and Chemical Engineering Year:2021 | Volume:40 | Issue:1 Page(s): 201-206

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Information Journal Paper

Title

Synthesis, Characterization, and Study of Anti-Tubercular and Anti-Microbial Activity of Isonicotinohydrazide Tridentate Schiff Base Ligands

Author(s)

PAHLAVANI ELHAM | KARGAR HADI | Issue Writer Certificate

Keywords

Schiff base

Isonicotinohydrazide

Anti-tubercular

Anti-microbial

Abstract

New Schiff bases derived by the condensation of isonicotinoylhydrazide and 2-hydroxy-3-methoxy-benzaldehyde and 2, 4-dihydroxybenzaldehyde have been synthesized. Compounds were characterized on the basis of various spectroscopic techniques like IR, 1H and 13C NMR studies, elemental analysis. The ligands were subjected to Anti-microbial and Anti-tubercular activity screening using serial broth dilution method and Minimum Inhibitory Concentration (MIC) is determined. The ligands were evaluated for their Anti-microbial activity against Gram-positive bacteria (Staphylococcus aureus ATCC 9144) and Gram-negative bacterium (Escherichia coli ATCC 11303). Therefore, newly synthesized ligands showed good biological activity against tested bacteria. Compounds show high levels of activity against Mycobacterium tuberculosis (M. tuberculosis H37RV) in vitro.

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APA: Copy

PAHLAVANI, ELHAM, & KARGAR, HADI. (2021). Synthesis, Characterization, and Study of Anti-Tubercular and Anti-Microbial Activity of Isonicotinohydrazide Tridentate Schiff Base Ligands. IRANIAN JOURNAL OF CHEMISTRY AND CHEMICAL ENGINEERING (IJCCE), 40(1), 201-206. SID. https://sid.ir/paper/775367/en

Vancouver: Copy

PAHLAVANI ELHAM, KARGAR HADI. Synthesis, Characterization, and Study of Anti-Tubercular and Anti-Microbial Activity of Isonicotinohydrazide Tridentate Schiff Base Ligands. IRANIAN JOURNAL OF CHEMISTRY AND CHEMICAL ENGINEERING (IJCCE)[Internet]. 2021;40(1):201-206. Available from: https://sid.ir/paper/775367/en

IEEE: Copy

ELHAM PAHLAVANI, and HADI KARGAR, “Synthesis, Characterization, and Study of Anti-Tubercular and Anti-Microbial Activity of Isonicotinohydrazide Tridentate Schiff Base Ligands,” IRANIAN JOURNAL OF CHEMISTRY AND CHEMICAL ENGINEERING (IJCCE), vol. 40, no. 1, pp. 201–206, 2021, [Online]. Available: https://sid.ir/paper/775367/en

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