IN VITRO SUSTAINED RELEASE OF PYRIDOSTIGMIN BROMIDE FROM INJECTABLE THERMO SENSITIVE CHITOSAN HYDROGEL

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GANJI F.; HOOBAKHT F.; GHASEMI TAHRIR F.; VASHEGHANI FARAHANI E.

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Journal: IRANIAN JOURNAL OF BIOMEDICAL ENGINEERING Year:2014 | Volume:8 | Issue:3 Page(s): 249-260

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Title

IN VITRO SUSTAINED RELEASE OF PYRIDOSTIGMIN BROMIDE FROM INJECTABLE THERMO SENSITIVE CHITOSAN HYDROGEL

Author(s)

GANJI F. | HOOBAKHT F. | GHASEMI TAHRIR F. | VASHEGHANI FARAHANI E. | Issue Writer Certificate

Keywords

CHITOSANQ2

THERMO SENSITIVEQ2

INJECTABLEQ2

SUSTAINED RELEASEQ2

PYRIDOSTIGMINE BROMIDEQ2

Abstract

Soman is one of the strongest nerve agents and treatment of poisoning with Soman is difficult and time-critical. PYRIDOSTIGMINE BROMIDE is an inhibitor of cholinesterase used for protecting against toxicity by Soman. In this study, a new INJECTABLE THERMO SENSITIVE SUSTAINED RELEASE dosage form of PYRIDOSTIGMINE BROMIDE was achieved by CHITOSAN/glycerol phosphate solution. In this study, thermo sensitivity and rheological properties of CHITOSAN solution (2% w/v) in aqueous hydrochloric acid (0.1 molar) with different percent of glycerol phosphate salt as well as the release profile of PYRIDOSTIGMINE BROMIDE have been investigated. It was observed that increasing the glycerol phosphate salt concentration would increase the pH of CHITOSAN solution, while decrease its gelation time and loss or storage modulus. It was also observed that glycerol phosphate salt concentration has direct effect on hydrogel thermo reversibility. The presented results indicated that hydrogel containing 2% w/v of CHITOSAN and 16% w/v of glycerol phosphate salt could sustain the delivery of PYRIDOSTIGMINE BROMIDE, through Fickian diffusion, up to four days.

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APA: Copy

GANJI, F., HOOBAKHT, F., GHASEMI TAHRIR, F., & VASHEGHANI FARAHANI, E.. (2014). IN VITRO SUSTAINED RELEASE OF PYRIDOSTIGMIN BROMIDE FROM INJECTABLE THERMO SENSITIVE CHITOSAN HYDROGEL. IRANIAN JOURNAL OF BIOMEDICAL ENGINEERING, 8(3), 249-260. SID. https://sid.ir/paper/81604/en

Vancouver: Copy

GANJI F., HOOBAKHT F., GHASEMI TAHRIR F., VASHEGHANI FARAHANI E.. IN VITRO SUSTAINED RELEASE OF PYRIDOSTIGMIN BROMIDE FROM INJECTABLE THERMO SENSITIVE CHITOSAN HYDROGEL. IRANIAN JOURNAL OF BIOMEDICAL ENGINEERING[Internet]. 2014;8(3):249-260. Available from: https://sid.ir/paper/81604/en

IEEE: Copy

F. GANJI, F. HOOBAKHT, F. GHASEMI TAHRIR, and E. VASHEGHANI FARAHANI, “IN VITRO SUSTAINED RELEASE OF PYRIDOSTIGMIN BROMIDE FROM INJECTABLE THERMO SENSITIVE CHITOSAN HYDROGEL,” IRANIAN JOURNAL OF BIOMEDICAL ENGINEERING, vol. 8, no. 3, pp. 249–260, 2014, [Online]. Available: https://sid.ir/paper/81604/en

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