APPLICATION OF MESOPOROUS SILICA NANOPARTICLES AS A DRUG DELIVERY SYSTEM FOR RIVASTIGMINE HYDROGEN TARTRATE

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KARIMZADEH MAH MONIR; RASHIDI LADAN; GANJI FARIBA; AHMADI MITRA; TAHMASEBI ENFERADI SATTAR

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Journal: IRANIAN JOURNAL OF BIOMEDICAL ENGINEERING Year:2015 | Volume:8 | Issue:4 Page(s): 386-399

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Title

APPLICATION OF MESOPOROUS SILICA NANOPARTICLES AS A DRUG DELIVERY SYSTEM FOR RIVASTIGMINE HYDROGEN TARTRATE

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Keywords

RIVASTIGMINE HYDROGEN TARTRATEQ2

MESOPOROUS SILICA NANOPARTICLESQ2

ALZIMER DISEASEQ2

Abstract

The aim of this research is a preparation of a system based on MESOPOROUS SILICA NANOPARTICLES (MSN) for delivery of RIVASTIGMINE HYDROGEN TARTRATE and study of the system cytotoxicity, with or without drug, on the human brain neuroblastoma cells (SY5Y). Rivastigmine is a hydrophilic and hydrophobic drug which is used for treatment of Alzimerʾs disease. In this study MSN were synthesized and characterized by scanning electron microscopy, transmission electron microscopy, Fourier transform infrared spectroscopy, x-ray diffraction, N2 adsorption isotherms, and z-potential analysis. Results showed that all MSN were spherical with the same structure. The mean size of nanoparticles was 100±13 nm and the mean diameter of pores was 2.15 nm. The loading capacity and efficiency of RIVASTIGMINE HYDROGEN TARTRATE were obtained 20.88, and 25%, respectively. Release of rivastigmine from nanoparticles in the simulated gastric and body fluid during 24 h were obtained 70.5 and 79.6%, respectively which was shown the slightly fast release of rivastigmine in simulated gastric fluid. The cytotoxicity effect of nanoparticles with and without rivastigmine was done by MTT assay on SY5Y cell lines. Results showed that the in vitro rivastigmine release from the nanoparticles containing of it exhibited the more treatment property as free rivastigmine on SY5Y.

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APA: Copy

KARIMZADEH, MAH MONIR, RASHIDI, LADAN, GANJI, FARIBA, AHMADI, MITRA, & TAHMASEBI ENFERADI, SATTAR. (2015). APPLICATION OF MESOPOROUS SILICA NANOPARTICLES AS A DRUG DELIVERY SYSTEM FOR RIVASTIGMINE HYDROGEN TARTRATE. IRANIAN JOURNAL OF BIOMEDICAL ENGINEERING, 8(4), 386-399. SID. https://sid.ir/paper/81646/en

Vancouver: Copy

KARIMZADEH MAH MONIR, RASHIDI LADAN, GANJI FARIBA, AHMADI MITRA, TAHMASEBI ENFERADI SATTAR. APPLICATION OF MESOPOROUS SILICA NANOPARTICLES AS A DRUG DELIVERY SYSTEM FOR RIVASTIGMINE HYDROGEN TARTRATE. IRANIAN JOURNAL OF BIOMEDICAL ENGINEERING[Internet]. 2015;8(4):386-399. Available from: https://sid.ir/paper/81646/en

IEEE: Copy

MAH MONIR KARIMZADEH, LADAN RASHIDI, FARIBA GANJI, MITRA AHMADI, and SATTAR TAHMASEBI ENFERADI, “APPLICATION OF MESOPOROUS SILICA NANOPARTICLES AS A DRUG DELIVERY SYSTEM FOR RIVASTIGMINE HYDROGEN TARTRATE,” IRANIAN JOURNAL OF BIOMEDICAL ENGINEERING, vol. 8, no. 4, pp. 386–399, 2015, [Online]. Available: https://sid.ir/paper/81646/en

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