PHARMACOKINETICS OF CEFTAZIDIME IN BUFFALO CALVES FOLLOWING INTRAVENOUS AND INTRAMUSCULAR ADMINISTRATION

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HAQ S.A.; SHARMA S.K.

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Paper Information

Journal: IRANIAN JOURNAL OF VETERINARY RESEARCH (IJVR) Year:2014 | Volume:15 | Issue:1 (46) Page(s): 18-22

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Title

PHARMACOKINETICS OF CEFTAZIDIME IN BUFFALO CALVES FOLLOWING INTRAVENOUS AND INTRAMUSCULAR ADMINISTRATION

Author(s)

HAQ S.A. | SHARMA S.K. | Issue Writer Certificate

Keywords

BUFFALO CALVESQ2

CEFTAZIDIMEQ2

DOSAGE REGIMENQ2

PHARMACOKINETICSQ2

Abstract

The pharmacokinetic parameters of CEFTAZIDIME, a third generation cephalosporin, were investigated in six BUFFALO CALVES after single intravenous (IV) and intramuscular (IM) administration at a dose rate of 10 mg/kg body weight. CEFTAZIDIME concentrations in plasma and urine were determined by microbiological assay. CEFTAZIDIME disposition was best fitted by a two-compartmental and a one-compartmental open model with first-order elimination after IV and IM dosing, respectively. After IV administration, distribution was rapid (t1/2a=0.15±0.01 h) with an area under the CEFTAZIDIME plasma concentration/time curve (AUC0-¥) of 253.9±7.8 mg/ml.h and a steady state volume of distribution (Vd (ss)) of 0.18±0.01 L.kg-1. The elimination half life (t1/2b) and total body clearance were 3.4±0.2 h and 39.5±1.2 ml/kg/h, respectively. Following intramuscular administration, the absorption half life (t1/2ka), peak plasma concentration (Cmax), time to peak plasma concentration (Tmax), AUC0-¥ and bioavailability were 0.25±0.04 h, 45.8±2.7 mg/ml, 0.75 h, 207.9±9.9 mg/ml.h and 81.7±5.9%, respectively. Urinary excretion of CEFTAZIDIME was less than 55% 36 h post administration. In vitro plasma protein binding of CEFTAZIDIME was 13.1±1.1%. To maintain minimum therapeutic concentration of 4 mg/ml, a satisfactory DOSAGE REGIMEN of CEFTAZIDIME in BUFFALO CALVES would be 9.4 mg/kg to be repeated at 12 h intervals. In conclusion, CEFTAZIDIME (10 mg/kg, IM) shows favorable pharmacokinetic behavior in BUFFALO CALVES.

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APA: Copy

HAQ, S.A., & SHARMA, S.K.. (2014). PHARMACOKINETICS OF CEFTAZIDIME IN BUFFALO CALVES FOLLOWING INTRAVENOUS AND INTRAMUSCULAR ADMINISTRATION. IRANIAN JOURNAL OF VETERINARY RESEARCH (IJVR), 15(1 (46)), 18-22. SID. https://sid.ir/paper/85648/en

Vancouver: Copy

HAQ S.A., SHARMA S.K.. PHARMACOKINETICS OF CEFTAZIDIME IN BUFFALO CALVES FOLLOWING INTRAVENOUS AND INTRAMUSCULAR ADMINISTRATION. IRANIAN JOURNAL OF VETERINARY RESEARCH (IJVR)[Internet]. 2014;15(1 (46)):18-22. Available from: https://sid.ir/paper/85648/en

IEEE: Copy

S.A. HAQ, and S.K. SHARMA, “PHARMACOKINETICS OF CEFTAZIDIME IN BUFFALO CALVES FOLLOWING INTRAVENOUS AND INTRAMUSCULAR ADMINISTRATION,” IRANIAN JOURNAL OF VETERINARY RESEARCH (IJVR), vol. 15, no. 1 (46), pp. 18–22, 2014, [Online]. Available: https://sid.ir/paper/85648/en

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